钙调蛋白对鸡砂囊平滑肌肌动球蛋白ATP酶活性及皮肤纤维收缩的抑制作用。
Caldesmon-induced inhibition of ATPase activity of actomyosin and contraction of skinned fibres of chicken gizzard smooth muscle.
作者信息
Szpacenko A, Wagner J, Dabrowska R, Rüegg J C
出版信息
FEBS Lett. 1985 Nov 11;192(1):9-12. doi: 10.1016/0014-5793(85)80032-6.
PMID:2932346
Abstract
Caldesmon induces inhibition of MG2+-ATPase activity of actomyosin and relaxation of skinned fibers of chicken gizzard smooth muscle without influencing the level of myosin light chain-1 phosphorylation. Both these effects are reversed by calmodulin at a high molar excess over caldesmon in the presence of Ca2+.
摘要
钙调蛋白诱导鸡胗平滑肌肌动球蛋白的Mg2+-ATP酶活性受到抑制，以及去表皮纤维松弛，而不影响肌球蛋白轻链-1的磷酸化水平。在Ca2+存在的情况下，当钙调蛋白的摩尔量大大超过钙调蛋白时，这两种效应都会被逆转。
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