College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University , Nanyang 473061, China.
Key Laboratory of Molecular Clinical Pharmacology & Fifth Affiliated Hospital, Guangzhou Medical University , Guangzhou, Guangdong 511436, China.
Org Lett. 2018 Feb 2;20(3):566-569. doi: 10.1021/acs.orglett.7b03673. Epub 2018 Jan 11.
A unique Co(III)-catalyzed and DMSO-involved C-H activation/cyclization of simple, cheap, and easily available anilines with alkynes for direct and highly efficient synthesis of privileged quinolines with exclusive regioselectivity and broad substrate/functional group tolerance and in good to excellent yields, where DMSO was employed as both the solvent and the C building block of quinoline products, is reported. Mechanistic experiments revealed that the versatile reaction might employ the 2-vinylbenzenamine species as the active intermediate.
报道了一种独特的 Co(III)催化、DMSO 参与的简单、廉价且易得的苯胺与炔烃的 C-H 活化/环化反应，用于直接、高效地合成具有独特区域选择性和广泛底物/官能团耐受性的喹啉，产率良好至优秀，其中 DMSO 既作为溶剂又作为喹啉产物的 C 构建块。机理实验表明，该多功能反应可能采用 2-乙烯基苯胺物种作为活性中间体。
