用于癌症治疗的生物素缀合有机分子和蛋白质：综述。
Biotin conjugated organic molecules and proteins for cancer therapy: A review.
机构信息
Department of Chemistry, School of Advanced Sciences, VIT University, Vellore 632014, Tamilnadu, India.
Department of Chemistry, School of Advanced Sciences, VIT University, Vellore 632014, Tamilnadu, India.
出版信息
Eur J Med Chem. 2018 Feb 10;145:206-223. doi: 10.1016/j.ejmech.2018.01.001. Epub 2018 Jan 2.
The main transporter for biotin is sodium dependent multivitamin transporter (SMVT), which is overexpressed in various aggressive cancer cell lines such as ovarian (OV 2008, ID8), leukemia (L1210FR), mastocytoma (P815), colon (Colo-26), breast (4T1, JC, MMT06056), renal (RENCA, RD0995), and lung (M109) cancer cell lines. Furthermore, its overexpression was found higher to that of folate receptor. Therefore, biotin demand in the rapidly growing tumors is higher than normal tissues. Several biotin conjugated organic molecules has been reported here for selective delivery of the drug in cancer cell. Biotin conjugated molecules are showing higher fold of cytotoxicity in biotin positive cancer cell lines than the normal cell. Nanoparticles and polymer surface modified drugs and biotin mediated cancer theranostic strategy was highlighted in this review. The cytotoxicity and selectivity of the drug in cancer cells has enhanced after biotin conjugation.
生物素的主要转运蛋白是钠离子依赖的多种维生素转运蛋白（SMVT），它在各种侵袭性癌细胞系中过度表达，如卵巢（OV 2008、ID8）、白血病（L1210FR）、肥大细胞瘤（P815）、结肠（Colo-26）、乳腺（4T1、JC、MMT06056）、肾脏（RENCA、RD0995）和肺癌（M109）细胞系。此外，它的过度表达被发现高于叶酸受体。因此，快速生长的肿瘤对生物素的需求高于正常组织。这里报道了几种生物素缀合的有机分子，用于在癌细胞中选择性地递药。与正常细胞相比，生物素缀合分子在生物素阳性癌细胞系中显示出更高的细胞毒性倍数。本文重点介绍了纳米颗粒和聚合物表面修饰药物以及生物素介导的癌症治疗策略。生物素缀合后，药物在癌细胞中的细胞毒性和选择性得到增强。
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