Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China.
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, PR China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan 430030, Hubei, PR China.
Environ Pollut. 2018 Apr;235:505-513. doi: 10.1016/j.envpol.2017.12.074. Epub 2018 Jan 8.
Fine particle (PM)-related lung damage has been reported in most studies regarding environmental or personal PM concentrations. To assess effects of personal PM exposures on lung function, we recruited 20 postgraduate students and estimated the individual doses of inhaled PM based on their microenvironmetal PM concentrations, time-activity patterns and refereed inhalation rates. During the period of seven consecutive days in each of the four seasons, we repeatedly measured the daily lung function parameters and airway inflammation makers such as fractional exhaled nitric oxide (FeNO) as well as systemic inflammation markers including interleukin-1β on the final day. The high individual dose (median (IQR)) of inhaled PM was 957 (948) μg/day. We observed a maximum FeNO increase (9.1% (95%CI: 2.2-15.5)) at lag 0 day, a maximum decrease of maximum voluntary ventilation (11.8% (95% CI: 4.6-19.0)) at lag 5 day and a maximum interleukin-1β increase (103% (95% CI: 47-159)) at lag 2 day for an interquartile range increase in the individual dose of inhaled PM during the four seasons. Short-term exposure to PM assessed by the individual dose of inhaled PM was associated with higher airway and systemic inflammation and reduced lung function. Further studies are needed to understand better underlying mechanisms of lung damage following acute exposure to PM
已有研究报道，在环境或个人 PM 浓度相关研究中，细颗粒物（PM）与肺部损伤相关。为了评估个人 PM 暴露对肺功能的影响，我们招募了 20 名研究生，根据他们的微环境 PM 浓度、时间-活动模式和参考吸入率，估算了吸入 PM 的个体剂量。在四个季节的连续七天期间，我们在每天测量肺功能参数和气道炎症标志物（如呼出气一氧化氮分数（FeNO））以及炎症标志物（包括白细胞介素-1β），最后一天测量。吸入 PM 的个体剂量高（中位数（IQR））为 957（948）μg/天。我们观察到，在滞后 0 天，FeNO 最大增加（9.1%（95%CI：2.2-15.5）），在滞后 5 天，最大用力呼气量（MVV）最大下降（11.8%（95%CI：4.6-19.0）），在滞后 2 天，白细胞介素-1β最大增加（103%（95%CI：47-159）），与四个季节吸入 PM 的个体剂量的四分位距增加相关。PM 的个体剂量评估的短期暴露与更高的气道和全身炎症以及肺功能下降有关。需要进一步的研究来更好地了解急性 PM 暴露后肺部损伤的潜在机制。
