创伤患者的储存损伤与输血
Storage injury and blood transfusions in trauma patients.
作者信息
Spieth Peter M, Zhang Haibo
机构信息
Department of Anesthesiology and Critical Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Keenan Research Center for Biomedical Sciences, St. Michael's Hospital.
出版信息
Curr Opin Anaesthesiol. 2018 Apr;31(2):234-237. doi: 10.1097/ACO.0000000000000565.
PURPOSE OF REVIEW
The aim of the present review was to concisely summarize recent studies and current knowledge about effects of red blood cell storage injury in trauma patients.
RECENT FINDINGS
Despite a pathophysiological rationale for older packed red blood cells (PRBCs) being associated with adverse events in the host organism, recent large clinical trials failed to show negative effects of transfusion with older PRBCs on clinically relevant outcomes in mixed patient population. However, there is a lack of well-designed randomized controlled trials focusing on the effects of storage lesion of PRBCs in trauma patients.
SUMMARY
In the absence of specific evidence for trauma patients, we recommend to continue with a conservative transfusion regime and standard of care blood banking practice of using older PRBCs first.
综述目的
本综述的目的是简要总结近期关于创伤患者红细胞储存损伤影响的研究及当前认知。
近期发现
尽管有病理生理学依据表明陈旧的浓缩红细胞（PRBCs）与宿主机体不良事件相关，但近期大型临床试验未能显示输注陈旧PRBCs对混合患者群体的临床相关结局有负面影响。然而，缺乏针对创伤患者PRBCs储存损伤影响的精心设计的随机对照试验。
总结
在缺乏针对创伤患者的具体证据的情况下，我们建议继续采用保守的输血方案以及优先使用陈旧PRBCs的标准血库操作规范。
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