血清素及其拮抗剂酮色林对软脑膜血管的影响。

Effect of serotonin and its antagonist ketanserin on pial vessels.

作者信息

Auer L M, Leber K, Sayama I

出版信息

J Cereb Blood Flow Metab. 1985 Dec;5(4):517-22. doi: 10.1038/jcbfm.1985.78.

DOI:10.1038/jcbfm.1985.78

Abstract

The effect of serotonin (5-HT) and its antagonist ketanserin on the cerebral circulation was investigated in two series totaling 24 cats using the cranial window technique. 5-HT elicited a marked dilatation of small pial arteries, whereas large arteries tended to constrict. Intravenous administration of ketanserin reversed the constriction of large arteries, causing dilatation, and reduced the extent of small arteries' dilatation. In a randomized study, i.v. administration of ketanserin in its solvent versus the solvent alone revealed a strong dilatatory effect of the solvent on pial arteries (17 +/- 1.8%), which partly jeopardized a possible constrictory effect of ketanserin, as ketanserin plus solvent induced less dilatation of small pial arteries than the solvent alone. The present data support the view that serotonin exerts a dual effect on cerebral arteries, namely, dilatation of small and constriction of large vessels. The antagonist ketanserin reverses this effect, but the strong dilatatory effect of the solvent alone masks the antiserotoninergic effect.

摘要

利用颅骨开窗技术，在总共24只猫身上分两个系列研究了血清素（5-羟色胺，5-HT）及其拮抗剂酮色林对脑循环的影响。5-HT引起软脑膜小动脉显著扩张，而大动脉则倾向于收缩。静脉注射酮色林可逆转大动脉的收缩，使其扩张，并减少小动脉的扩张程度。在一项随机研究中，静脉注射溶解于溶剂中的酮色林与单独注射溶剂相比，结果显示溶剂对软脑膜动脉有很强的扩张作用（17±1.8%），这在一定程度上掩盖了酮色林可能的收缩作用，因为酮色林加溶剂引起的软脑膜小动脉扩张比单独使用溶剂时要小。目前的数据支持以下观点：血清素对脑动脉有双重作用，即小血管扩张和大血管收缩。拮抗剂酮色林可逆转这种作用，但单独使用溶剂的强扩张作用掩盖了抗血清素能作用。