Department of Neurology, Ruijin Hospital affiliated with the School of Medicine, Shanghai Jiao Tong University, 197 Ruijin No. 2 Road, Shanghai, 200025, China; School of Public Health, Shanghai Jiao Tong University, 227 Chong Qing Nan Road, Shanghai, 200025, China.
Department of Learning, Informatics, Management and Ethics, Karolinska Institute, Stockholm, 17177, Sweden.
Brain Res Bull. 2018 Mar;137:301-305. doi: 10.1016/j.brainresbull.2018.01.005. Epub 2018 Jan 9.
Serum level of Haptoglobin (Hp) maybe associated with Alzheimer's disease (AD) and mild cognitive impairment (MCI).
To investigate associations between serum Hp and AD, as well as between Hp and MCI.
Serum levels of Hp were measured and analyzed for 51 patients with AD, 139 patients with MCI and their healthy controls matched with sex and age. All study subjects were from a survey among residents aged 60 years and over in a community located in the southwest suburb of Shanghai.
Serum levels of Hp were observed significantly higher in AD and MCI cases than controls (both p < 0.0001). A significant positive correlation was found between Hp and Activities of Daily Living (ADL) score (r = 0.430, p = 0.007), as well as between Hp and Clinical Dementia Rating (CDR) score (r = 0.359, p = 0.027) in all AD patients. According to the receiver operating characteristic (ROC) curve analysis, the optimal cut-off point for Hp was found to be 67.50 μg/ml (sensitivity, 0.902; specificity, 0.745) in AD patients, and 44.76 μg/ml (sensitivity, 0.986; specificity, 0.403) in MCI patients.
Elevated serum levels of Hp were observed in AD and MCI patients than controls. In addition, Hp may correlate with the severity of AD.
血清结合珠蛋白（Hp）水平可能与阿尔茨海默病（AD）和轻度认知障碍（MCI）有关。
研究血清 Hp 与 AD 以及与 MCI 之间的关系。
对 51 例 AD 患者、139 例 MCI 患者及其性别和年龄相匹配的健康对照者进行血清 Hp 水平测量和分析。所有研究对象均来自上海西南郊区某社区 60 岁及以上居民的一项调查。
AD 和 MCI 患者的血清 Hp 水平明显高于对照组（均 p<0.0001）。在所有 AD 患者中，Hp 与日常生活活动能力（ADL）评分（r=0.430，p=0.007）以及与临床痴呆评定量表（CDR）评分（r=0.359，p=0.027）之间存在显著正相关。根据受试者工作特征（ROC）曲线分析，发现 Hp 的最佳截断值在 AD 患者中为 67.50μg/ml（灵敏度为 0.902，特异性为 0.745），在 MCI 患者中为 44.76μg/ml（灵敏度为 0.986，特异性为 0.403）。
AD 和 MCI 患者的血清 Hp 水平高于对照组。此外，Hp 可能与 AD 的严重程度有关。
