Irimajiri N, Bloom E T, Makinodan T
Mech Ageing Dev. 1985 Jul-Aug;31(2):155-62. doi: 10.1016/s0047-6374(85)80026-9.
Natural killer (NK) cell activity declines with age in mice. The purpose of this study was to investigate the effect of peritoneal and splenic adherent cells from young and old mice on NK activity to determine whether adherent cell suppressor function might contribute to this decline. Peritoneal adherent cells from old mice suppressed NK activity of young splenic non-adherent indicator cells more than peritoneal cells from young mice. Splenic adherent cells from old but not from young mice also suppressed this activity. That (1) the suppressive activity of the adherent cell populations was not affected by treatment with anti-Thy-1 plus complement, and that (2) the adherent cell population contained 77-92% cells positive for alpha-naphthyl acetate esterase activity, suggests that the active adherent suppressor cell may be a macrophage. Therefore, the age-related decline in NK activity in mice can be explained, in part, by an increase in adherent cell suppressor function.
在小鼠中，自然杀伤（NK）细胞的活性会随着年龄增长而下降。本研究的目的是调查来自年轻和年老小鼠的腹膜及脾脏贴壁细胞对NK活性的影响，以确定贴壁细胞的抑制功能是否可能导致了这种下降。年老小鼠的腹膜贴壁细胞对年轻脾脏非贴壁指示细胞NK活性的抑制作用比年轻小鼠的腹膜细胞更强。来自年老而非年轻小鼠的脾脏贴壁细胞也抑制了这种活性。（1）贴壁细胞群体的抑制活性不受抗Thy-1加补体处理的影响，且（2）贴壁细胞群体中77-92%的细胞α-萘乙酸酯酶活性呈阳性，这表明活性贴壁抑制细胞可能是巨噬细胞。因此，小鼠中与年龄相关的NK活性下降部分可以通过贴壁细胞抑制功能的增强来解释。
