Blair P B, Staskawicz M O, Sam J S
Department of Microbiology and Immunology, University of California, Berkeley 94720.
Mech Ageing Dev. 1987 Sep 14;40(1):57-70. doi: 10.1016/0047-6374(87)90034-0.
Spleen cells from female mice of the recombinant inbred strain BPS lack natural killer (NK) cytolytic activity, and can suppress the cytolytic activity of normal NK effector cells. The suppressor cells are not typical B cells, T cells, macrophages, or NK cells; they lack the characteristics and surface markers of each of these cell types. In BPS mice, suppressor cell activity is a dominant and significant characteristic of spleen cells at every age tested (2 weeks to 18 months). In other strains of mice which are normally classified as high-responders in NK assays, such as the C57BL strain, these suppressor cells are less prominent but can be detected when separated (on the basis of their higher density) from other spleen cell populations. As mice of the high-responder strains age, however, the suppressor cells become a significant part of the spleen cell population.
重组近交系BPS雌性小鼠的脾细胞缺乏自然杀伤（NK）细胞溶解活性，并且能够抑制正常NK效应细胞的细胞溶解活性。抑制细胞不是典型的B细胞、T细胞、巨噬细胞或NK细胞；它们缺乏这些细胞类型各自的特征和表面标志物。在BPS小鼠中，抑制细胞活性是每个测试年龄（2周龄至18月龄）的脾细胞的一个主要且显著的特征。在NK检测中通常被归类为高反应者的其他小鼠品系，如C57BL品系，这些抑制细胞不太突出，但当从其他脾细胞群体中（基于其较高的密度）分离出来时可以被检测到。然而，随着高反应者品系小鼠年龄的增长，抑制细胞成为脾细胞群体的一个重要组成部分。
