苯丙酮尿症患者血液中苯丙氨酸的不稳定性与焦虑密切相关。
Blood phenylalanine instability strongly correlates with anxiety in phenylketonuria.
作者信息
Didycz Bozena, Bik-Multanowski Miroslaw
机构信息
Department of Medical Genetics, Jagiellonian University Medical College, Krakow, Poland.
出版信息
Mol Genet Metab Rep. 2017 Dec 27;14:80-82. doi: 10.1016/j.ymgmr.2017.12.003. eCollection 2018 Mar.
Abstract
We assessed the relationship between anxiety and long-term metabolic control in adolescents with phenylketonuria (PKU). We used a standardized psychological test to measure anxiety level and analyzed lifelong blood phenylalanine stability in a selected group of 25 PKU teenagers with treatment adherence problems. We demonstrated significant correlations of anxiety with variability of blood phenylalanine concentrations and with severity of hyperphenylalaninemia. Avoiding blood phenylalanine fluctuations in childhood can probably reduce anxiety in PKU adolescents.
摘要
我们评估了苯丙酮尿症（PKU）青少年焦虑与长期代谢控制之间的关系。我们使用标准化心理测试来测量焦虑水平，并分析了25名有治疗依从性问题的PKU青少年特定群体的终身血苯丙氨酸稳定性。我们证明焦虑与血苯丙氨酸浓度变异性以及高苯丙氨酸血症严重程度之间存在显著相关性。在儿童期避免血苯丙氨酸波动可能会降低PKU青少年的焦虑。
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