Zourbas J, Fauchet R, Le Hesran J Y, Denis B
Presse Med. 1985 Sep 28;14(32):1701-3.
One hundred dental surgeons practising in western France were immunized against hepatitis B virus, using the same batch of HEVAC B vaccine from the Pasteur Institute. The vaccine was very well tolerated. Seroconversion at 10 m IU/ml was 94% after 3 injections and 98% after the booster dose. From a kinetic study of anti-HBs antibodies we were able to determine different levels of post-immunization serological response and to classify responders as very good, good and fairly good. The effectiveness of the booster dose was manifest after 10 days. In view of the efficacy and safety of this vaccine, confirmed by other studies in sanitary personnel, we do not hesitate to recommend it to dental surgeons exposed to the disease.
法国西部的100名牙科外科医生使用巴斯德研究所同一批次的HEVAC B疫苗接种了乙肝病毒疫苗。该疫苗耐受性良好。三次注射后,抗-HBs抗体水平达到10 mIU/ml的血清转化率为94%,加强剂量后为98%。通过对抗-HBs抗体的动力学研究,我们能够确定免疫后不同水平的血清学反应,并将反应者分为非常好、好和较好三类。加强剂量的有效性在10天后显现。鉴于该疫苗的有效性和安全性已在卫生人员的其他研究中得到证实,我们毫不犹豫地向接触该疾病的牙科外科医生推荐它。