硫酸乙酰肝素蛋白聚糖-1 作为预测腹部大手术后脓毒症患者生存的生物标志物。
Syndecan-1 as a biomarker for sepsis survival after major abdominal surgery.
机构信息
Department of Anesthesiology, Center of Anesthesiology & Intensive Care, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246, Hamburg, Germany.
Department of Anesthesiology & Intensive Care Asklepios Clinic Harburg, Eißendorfer Pferdeweg 52, 21052 Hamburg, Germany.
出版信息
Biomark Med. 2018 Feb;12(2):119-127. doi: 10.2217/bmm-2017-0231. Epub 2018 Jan 12.
AIM
Sepsis is a serious complication following surgery and identification of patients at risk is of high importance. Syndecan-1 (sSDC1) levels are known to be elevated during sepsis.
MATERIALS & METHODS: Fifty-five patients scheduled for major abdominal surgery were prospectively included and sSDC1 concentrations were measured during hospital stay.
RESULTS
Patients with postoperative sepsis showed a continued increase of sSDC1 levels and exhibited higher median sSDC1 concentrations at day 1 compared with nonseptic patients 90.3 versus 16.5 ng/ml. A significant association of sSDC1 levels with the incidence of sepsis and death was demonstrated.
CONCLUSION
This study identifies sSDC1 as potential biomarker for sepsis and survival after abdominal surgery.
目的
败血症是手术后的严重并发症，识别高危患者至关重要。已知在败血症期间， syndecan-1（sSDC1）水平升高。
材料和方法
前瞻性纳入 55 名接受大腹部手术的患者，并在住院期间测量 sSDC1 浓度。
结果
术后败血症患者的 sSDC1 水平持续升高，与非败血症患者相比，第 1 天的 sSDC1 中位数浓度更高，分别为 90.3 与 16.5ng/ml。sSDC1 水平与败血症和死亡的发生率存在显著相关性。
结论
本研究确定 sSDC1 是腹部手术后败血症和生存的潜在生物标志物。
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