Waldoch Jennifer A, Cox Sherry K, Armstrong Douglas L
J Avian Med Surg. 2017 Dec;31(4):314-318. doi: 10.1647/2016-222.
We determined the pharmacokinetic properties of ceftiofur crystalline-free acid (CCFA), a long-acting antibiotic, after a single intramuscular injection in cattle egrets ( Bubulcus ibis). A dose of 20 mg/kg was administered intramuscularly to 18 birds and blood samples were collected via jugular venipuncture at 1, 2, 4, 8, 12, 24, 48, 72, 96, 120, 144, 168, 192, 216, and 240 hours after CCFA administration. Plasma concentrations of ceftiofur free acid equivalents (CFAEs) were measured via high-performance liquid chromatography. The minimum inhibitory concentration (MIC) of 1 μg/mL was reached by 1 hour after administration and remained higher than the MIC for at least 72 hours in all birds. This target concentration is effective for many bacterial infections in avian species. The area under the plasma concentration versus time curve was 451.3 h*μg/mL, maximum plasma concentration was 16.22 μg/mL, time to maximum plasma concentration was 3.2 hours, mean harmonic half-life was 37.92 hours, and time that the concentrations of CFAEs were higher than the target MIC was a minimum of 72 hours.
我们测定了长效抗生素头孢噻呋无结晶游离酸（CCFA）在牛背鹭单次肌肉注射后的药代动力学特性。给18只鸟肌肉注射20mg/kg的剂量，并在注射CCFA后的1、2、4、8、12、24、48、72、96、120、144、168、192、216和240小时通过颈静脉穿刺采集血样。通过高效液相色谱法测定血浆中头孢噻呋游离酸当量（CFAEs）的浓度。给药后1小时达到1μg/mL的最低抑菌浓度（MIC），并且在所有鸟类中至少72小时内保持高于MIC。该目标浓度对鸟类的许多细菌感染有效。血浆浓度-时间曲线下面积为451.3h*μg/mL，血浆最大浓度为16.22μg/mL，达到血浆最大浓度的时间为3.2小时，平均谐波半衰期为37.92小时，CFAEs浓度高于目标MIC的时间至少为72小时。
