Shivappa Nitin, Hébert James R, Rashidkhani Bahram, Ghanavati Matin
1 Cancer Prevention and Control Program, University of South Carolina, Columbia, USA.
2 Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, USA.
Int J Vitam Nutr Res. 2017 Mar;87(1-2):17-24. doi: 10.1024/0300-9831/a000420. Epub 2018 Jan 12.
Background: In previous studies, diet has been shown to be associated with cataract. However, no study to date has focused on the association between inflammatory potential of diet and cataract.
In this case-control study conducted in Iran, we examined the association of the dietary inflammatory index (DII®) and cataract.
This case-control study included 97 cataract cases and 198 healthy controls hospitalized for acute non-neoplastic diseases with the control group matched according to age (with a five-year interval) and sex with the case group. The DII was computed based on dietary intake assessed by a previously validated food frequency questionnaire. Multivariable logistic regression models were used to estimate odds ratios (ORs), with the DII analyzed as both continuous and as tertiles. Energy was adjusted using the residual method.
Subjects with higher DII scores (i.e., with a more pro-inflammatory diet) had a higher odds of cataract, with the DII being used as both a continuous variable (ORcontinuous 1.51, 95% confidence interval, CI, 1.13 - 2.03; one unit increase corresponding to ≈18% of its range in the current study) and as tertiles (ORtertile3vs1 2.67, 95%CI 1.32 - 5.48, Ptrend = 0.002).
These results indicate that a pro-inflammatory diet is associated with increased risk of cataract. Additional studies should be conducted to further explore this association.
背景：在以往的研究中，饮食已被证明与白内障有关。然而，迄今为止尚无研究关注饮食的炎症潜能与白内障之间的关联。
在伊朗进行的这项病例对照研究中，我们研究了饮食炎症指数（DII®）与白内障之间的关联。
这项病例对照研究纳入了97例白内障患者和198例因急性非肿瘤性疾病住院的健康对照，对照组根据年龄（间隔5年）和性别与病例组匹配。DII是根据先前验证的食物频率问卷评估的饮食摄入量计算得出的。使用多变量逻辑回归模型估计比值比（OR），将DII作为连续变量和三分位数进行分析。能量采用残差法进行调整。
DII得分较高（即饮食具有更强促炎作用）的受试者患白内障的几率更高，DII作为连续变量时（OR连续 1.51，95%置信区间，CI，1.13 - 2.03；在本研究中，一个单位的增加相当于其范围的约18%）以及作为三分位数时（OR三分位数3对1 2.67，95%CI 1.32 - 5.48，P趋势 = 0.002）均如此。
这些结果表明促炎饮食与白内障风险增加有关。应开展更多研究以进一步探索这种关联。
