Department of Traditional Chinese Medicine Orthopaedics, Chinese Traditional Medicine Hospital of Wenzhou, Wenzhou, Zhejiang 325000, P.R. China.
Mol Med Rep. 2018 Mar;17(3):4791-4796. doi: 10.3892/mmr.2018.8389. Epub 2018 Jan 8.
Garcinia angustifolia is a dry resin secreted by Garcinia cambogia, which has the functions of breaking blood, detoxifying, stopping bleeding and killing insects. It is used for the treatment of cancer and brain edema. Gambogic acid is the primary active ingredient. The present study aimed to investigate the anti‑inflammatory and antiproliferative effects of gambogic acid on arthritis and the possible mechanisms. It was demonstrated that gambogic acid decreased arthritic scores in murine collagen‑induced arthritic mice. The tumor necrosis factor (TNF)‑α, interleukin (IL)‑1β, IL‑6 and IL‑18 concentrations, and caspase‑3 and caspase‑9 were significantly inhibited by gambogic acid in arthritic mice. Gambogic acid decreased matrix metalloproteinases (MMP)‑2, MMP‑9, nuclear factor (NF)‑κB and phosphorylated‑p38 protein expression, and increased tissue inhibitors of matrix metalloproteases‑1 (TIMP‑1) protein expression in arthritic mice. Furthermore, the phosphoinositide 3‑kinase (PI3K)/AKT serine/threonine kinase (Akt) signaling pathway was induced in arthritic mice treated with gambogic acid. The results suggested that gambogic acid induced anti‑inflammatory effects in murine collagen‑induced arthritis, through the PI3K/Akt signaling pathway, and offers future potential for application in arthritis patients.
藤黄是藤黄果实分泌的一种干燥树脂，具有破血、解毒、止血、杀虫的功效。用于治疗癌症和脑水肿。藤黄酸是主要的活性成分。本研究旨在探讨藤黄酸对关节炎的抗炎和抗增殖作用及其可能的机制。研究表明，藤黄酸可降低胶原诱导性关节炎小鼠的关节炎评分。藤黄酸可显著抑制关节炎小鼠肿瘤坏死因子 (TNF)-α、白细胞介素 (IL)-1β、IL-6 和 IL-18 浓度，以及 caspase-3 和 caspase-9。藤黄酸可降低关节炎小鼠基质金属蛋白酶 (MMP)-2、MMP-9、核因子 (NF)-κB 和磷酸化 p38 蛋白的表达，增加组织抑制剂基质金属蛋白酶-1 (TIMP)-1 蛋白的表达。此外，在藤黄酸治疗的关节炎小鼠中诱导了磷酸肌醇 3-激酶 (PI3K)/丝氨酸/苏氨酸激酶 (Akt) 信号通路。结果表明，藤黄酸通过 PI3K/Akt 信号通路诱导了胶原诱导性关节炎小鼠的抗炎作用，为关节炎患者的应用提供了未来的潜力。
