Onsrud M, Paus E, Haug E, Kjørstad K
Acta Obstet Gynecol Scand. 1985;64(6):519-23. doi: 10.3109/00016348509156732.
A radio-immunoassay for the determination of the serum concentration of hydroxyprogesterone caproate (HPC) was established. After a single intramuscular injection of 1000 mg, the mean serum level reached its maximum (44-81 nmol/l) after 2-7 days. Patients on long-term adjuvant HPC treatment (consisting of 1000 mg daily for 5 days followed by 1000 mg every 2 weeks) presented peak hormone levels 2 weeks after commencing treatment. After a drop at 5 weeks, the mean serum level slowly increased again to 130 nmol/l after 25 weeks of treatment. Patients being treated with weekly injections had significantly higher serum levels than those treated every 2 weeks. Considerable inter-individual differences were observed. The serum concentrations of HPC measured in this study compare favorably with those previously found in patients treated with medroxyprogesterone acetate. The patients on adjuvant HPC showed no significant change in the levels of cortisol, dehydroepiandrosterone sulphate, androstenedione, or estrone during the first 25 weeks of treatment.
建立了一种用于测定血清己酸羟孕酮（HPC）浓度的放射免疫分析法。单次肌内注射1000毫克后，血清平均水平在2至7天后达到最高值（44 - 81纳摩尔/升）。接受长期辅助HPC治疗的患者（每日1000毫克，共5天，随后每2周1000毫克）在开始治疗2周后出现激素水平峰值。在5周时有所下降后，治疗25周后血清平均水平再次缓慢升至130纳摩尔/升。每周注射治疗的患者血清水平显著高于每2周注射治疗的患者。观察到个体间存在相当大的差异。本研究中测得的HPC血清浓度与先前接受醋酸甲羟孕酮治疗的患者所测得的浓度相比更具优势。在辅助HPC治疗的前25周，患者的皮质醇、硫酸脱氢表雄酮、雄烯二酮或雌酮水平无显著变化。
