Onsrud M
Acta Obstet Gynecol Scand. 1985;64(2):179-82. doi: 10.3109/00016348509154714.
Serum levels of triglycerides, total cholesterol, and HDL-cholesterol were determined in 57 patients who were undergoing treatment for stage I endometrial carcinoma. The patients belonged to a clinical trial where group A (control) was treated with surgery plus intravaginal irradiation, whereas group B in addition was treated with hydroxyprogesterone caproate (5000 mg i.m. as a loading dose followed by 1000 mg every 2 weeks for one year). In group B patients followed during the first 13 weeks of treatment, the level of serum triglycerides remained stable, whereas the level of total cholesterol and HDL-cholesterol increased significantly. This increase could not, however, have been caused by the progestogen treatment, as similar changes were seen in group A patients followed for the same period of time. Long-term effects were looked for in patient groups examined 3-12 months after the start of treatment and in groups examined 3-6 months after the hormone therapy was stopped. In neither group could any significant difference in cholesterol or HDL-cholesterol be found. It is concluded that this type of progestogen treatment causes no significant change in the levels of triglycerides, cholesterol, and HDL-cholesterol.
对57例接受I期子宫内膜癌治疗的患者测定了血清甘油三酯、总胆固醇和高密度脂蛋白胆固醇水平。这些患者参与了一项临床试验，其中A组（对照组）接受手术加阴道内照射治疗，而B组除上述治疗外，还接受己酸羟孕酮治疗（静脉注射5000 mg作为负荷剂量，随后每2周注射1000 mg，持续一年）。在治疗的前13周对B组患者进行随访，血清甘油三酯水平保持稳定，而总胆固醇和高密度脂蛋白胆固醇水平显著升高。然而，这种升高不可能是由孕激素治疗引起的，因为在同期随访的A组患者中也观察到了类似的变化。在治疗开始后3 - 12个月检查的患者组以及激素治疗停止后3 - 6个月检查的患者组中寻找长期影响。在两组中均未发现胆固醇或高密度脂蛋白胆固醇有任何显著差异。得出的结论是，这种类型的孕激素治疗不会使甘油三酯、胆固醇和高密度脂蛋白胆固醇水平发生显著变化。
