• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

快照:线粒体类核。

SnapShot: Mitochondrial Nucleoid.

机构信息

Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, D-50931 Cologne, Germany.

Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, D-50931 Cologne, Germany; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden.

出版信息

Cell. 2018 Jan 11;172(1-2):388-388.e1. doi: 10.1016/j.cell.2017.12.039.

DOI:10.1016/j.cell.2017.12.039
PMID:29328920
Abstract

Mitochondrial DNA is compacted into nucleoprotein complexes denoted mitochondrial nucleoids, the focus of this SnapShot.

摘要

线粒体 DNA 被压缩成称为线粒体类核的核蛋白复合物,这是本 SnapShot 的重点。

相似文献

1
SnapShot: Mitochondrial Nucleoid.快照:线粒体类核。
Cell. 2018 Jan 11;172(1-2):388-388.e1. doi: 10.1016/j.cell.2017.12.039.
2
The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels.TFAM 与 mtDNA 的比值定义了具有不同活性水平的细胞内核仁群体。
Cell Rep. 2021 Nov 23;37(8):110000. doi: 10.1016/j.celrep.2021.110000.
3
To be or not to be a nucleoid protein: a comparison of mass-spectrometry based approaches in the identification of potential mtDNA-nucleoid associated proteins.是否成为一种类核蛋白:基于质谱分析方法在鉴定潜在的线粒体DNA-类核相关蛋白中的比较
Biochimie. 2014 May;100:219-26. doi: 10.1016/j.biochi.2013.09.017. Epub 2013 Sep 25.
4
Mitochondrial nucleoids undergo remodeling in response to metabolic cues.线粒体类核体会根据代谢信号进行重塑。
J Cell Sci. 2008 Jun 1;121(11):1861-8. doi: 10.1242/jcs.028605. Epub 2008 May 13.
5
Mitochondrial DNA Transport in Drosophila Neurons.果蝇神经元中的线粒体DNA转运
Methods Mol Biol. 2022;2431:409-416. doi: 10.1007/978-1-0716-1990-2_21.
6
The Mitochondrial Genome. The Nucleoid.线粒体基因组。拟核。
Biochemistry (Mosc). 2016 Oct;81(10):1057-1065. doi: 10.1134/S0006297916100047.
7
Mitochondrial nucleoid clusters protect newly synthesized mtDNA during Doxorubicin- and Ethidium Bromide-induced mitochondrial stress.线粒体类核簇在阿霉素和溴化乙锭诱导的线粒体应激过程中保护新合成的线粒体DNA。
Toxicol Appl Pharmacol. 2016 Jul 1;302:31-40. doi: 10.1016/j.taap.2016.04.011. Epub 2016 Apr 19.
8
Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid.TFAM与单个线粒体DNA分子的跨链结合形成线粒体核小体。
Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11288-93. doi: 10.1073/pnas.1512131112. Epub 2015 Aug 24.
9
mtDNA makes a U-turn for the mitochondrial nucleoid.线粒体 DNA 为线粒体拟核掉头。
Trends Cell Biol. 2013 Sep;23(9):457-63. doi: 10.1016/j.tcb.2013.04.009. Epub 2013 May 27.
10
Distribution of mitochondrial nucleoids upon mitochondrial network fragmentation and network reintegration in HEPG2 cells.线粒体网络碎片化和再整合过程中线粒体基因组的分布。
Int J Biochem Cell Biol. 2013 Mar;45(3):593-603. doi: 10.1016/j.biocel.2012.11.019. Epub 2012 Dec 7.

引用本文的文献

1
Assembly of the mitochondrial outer membrane module of the trypanosomal tripartite attachment complex.锥虫三联体附着复合体线粒体外膜模块的组装
PLoS Pathog. 2025 Sep 9;21(9):e1013506. doi: 10.1371/journal.ppat.1013506. eCollection 2025 Sep.
2
Biological and translational attributes of mitochondrial DNA copy number: Laboratory perspective to clinical relevance.线粒体DNA拷贝数的生物学和转化特性:从实验室视角到临床相关性
World J Methodol. 2025 Sep 20;15(3):102709. doi: 10.5662/wjm.v15.i3.102709.
3
Mitochondrial DNA depletion syndrome and its cardiac complication.
线粒体DNA耗竭综合征及其心脏并发症。
Front Cardiovasc Med. 2025 Jun 10;12:1582219. doi: 10.3389/fcvm.2025.1582219. eCollection 2025.
4
Mitochondrial dysfunction in the regulation of aging and aging-related diseases.线粒体功能障碍在衰老及衰老相关疾病调控中的作用
Cell Commun Signal. 2025 Jun 19;23(1):290. doi: 10.1186/s12964-025-02308-7.
5
Mitochondrial DNA signals driving immune responses: Why, How, Where?驱动免疫反应的线粒体DNA信号:为何、如何、何处?
Cell Commun Signal. 2025 Apr 22;23(1):192. doi: 10.1186/s12964-025-02042-0.
6
Mitochondrial DNA copy number alterations: Key players in the complexity of glioblastoma (Review).线粒体DNA拷贝数改变:胶质母细胞瘤复杂性中的关键因素(综述)
Mol Med Rep. 2025 Mar;31(3). doi: 10.3892/mmr.2025.13443. Epub 2025 Jan 31.
7
Molecular characterization of the permanent outer-inner membrane contact site of the mitochondrial genome segregation complex in trypanosomes.锥虫线粒体基因组分离复合体永久外-内膜接触位点的分子特征
PLoS Pathog. 2024 Dec 2;20(12):e1012635. doi: 10.1371/journal.ppat.1012635. eCollection 2024 Dec.
8
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.定位于线粒体的MBD2c促进线粒体DNA转录和耐药性。
Nat Chem Biol. 2025 Jun;21(6):926-938. doi: 10.1038/s41589-024-01776-1. Epub 2024 Nov 28.
9
High mitochondrial DNA levels accelerate lung adenocarcinoma progression.线粒体 DNA 水平升高可加速肺腺癌进展。
Sci Adv. 2024 Nov;10(44):eadp3481. doi: 10.1126/sciadv.adp3481. Epub 2024 Nov 1.
10
Aberrant fragmentomic features of circulating cell-free mitochondrial DNA as novel biomarkers for multi-cancer detection.循环游离线粒体DNA的异常片段组学特征作为多癌检测的新型生物标志物。
EMBO Mol Med. 2024 Dec;16(12):3169-3183. doi: 10.1038/s44321-024-00163-6. Epub 2024 Oct 30.