新诊断的 2 型糖尿病患者抑郁症状评分增加。

Increased depression symptom score in newly diagnosed type 2 diabetes patients.

机构信息

Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.

出版信息

Psychiatry Res. 2018 Mar;261:259-263. doi: 10.1016/j.psychres.2017.12.091. Epub 2018 Jan 3.

DOI:10.1016/j.psychres.2017.12.091

PMID:29329045

Abstract

The aim was to investigate the association between diabetes duration and depressive symptoms in type 2 diabetes. The DIAREG registry used data of a nationwide general medicine practice database (Disease Analyzer, Germany) augmented by prospective data from patient reported outcomes (PRO) including Center of Epidemiological Studies Depression Scale (CES-D: <16 vs. ≥16) and the SF-36. Multiple logistic regression models were used to investigate the association of diabetes duration with PROs. Overall, 1807 type 2 diabetes patients were registered in 108 practices. From 270 (15%) patients complete PRO could be collected, which were similar with respect to age, sex, body mass index, HbA1c, diabetes duration and treatment to patients with incomplete data (p≥0.05). Patients with a longer diabetes duration (reference: <2 years) displayed a significantly increased odds of having no indication of depression (CES-D <16: 66%) (Odds Ratio, 95%CI: 2-<5 years: 5.9, 1.2-29.6; 5-<10 years: 6.2, 1.3-28.7; ≥10 years: 5.6, 1.2-23.1), after adjusting for age, sex, BMI, diabetes complications, antidepressants and glucose-lowering treatment. Patients with <2 years diabetes duration also exhibited a significantly decreased mean mental component score (SF-36: <2 years: 50, 2-<5 years: 69). In type 2 diabetes with a short duration an increased depressive symptom score was observed.

摘要

目的在于探究 2 型糖尿病患者中糖尿病病程与抑郁症状之间的关联。DIAREG 登记研究利用了一项全国性普通医学实践数据库（德国疾病分析器）的数据，并通过前瞻性患者报告结局（PRO）数据进行了扩充，其中包括流行病学研究中心抑郁量表（CES-D：<16 与≥16）和 SF-36。采用多因素逻辑回归模型来探究糖尿病病程与 PRO 之间的关联。总体而言，108 家诊所共登记了 1807 名 2 型糖尿病患者。在 270 名（15%）完成完整 PRO 采集的患者中，与不完整数据患者（p≥0.05）相比，其年龄、性别、体重指数、HbA1c、糖尿病病程和治疗情况相似。与病程较短的患者（参考：<2 年）相比，病程较长的患者（CES-D<16：66%）出现抑郁症状（CES-D<16）的可能性显著降低（OR，95%CI：2-<5 年：5.9，1.2-29.6；5-<10 年：6.2，1.3-28.7；≥10 年：5.6，1.2-23.1），校正年龄、性别、BMI、糖尿病并发症、抗抑郁药和降糖治疗因素后仍具有统计学意义。病程<2 年的患者的 SF-36 心理成分评分也显著降低（<2 年：50，2-<5 年：69）。在病程较短的 2 型糖尿病患者中，抑郁症状评分有所升高。