Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.
Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Institute for Diabetes Research at Heinrich Heine University, Düsseldorf, Germany.
Psychiatry Res. 2018 Mar;261:259-263. doi: 10.1016/j.psychres.2017.12.091. Epub 2018 Jan 3.
The aim was to investigate the association between diabetes duration and depressive symptoms in type 2 diabetes. The DIAREG registry used data of a nationwide general medicine practice database (Disease Analyzer, Germany) augmented by prospective data from patient reported outcomes (PRO) including Center of Epidemiological Studies Depression Scale (CES-D: <16 vs. ≥16) and the SF-36. Multiple logistic regression models were used to investigate the association of diabetes duration with PROs. Overall, 1807 type 2 diabetes patients were registered in 108 practices. From 270 (15%) patients complete PRO could be collected, which were similar with respect to age, sex, body mass index, HbA1c, diabetes duration and treatment to patients with incomplete data (p≥0.05). Patients with a longer diabetes duration (reference: <2 years) displayed a significantly increased odds of having no indication of depression (CES-D <16: 66%) (Odds Ratio, 95%CI: 2-<5 years: 5.9, 1.2-29.6; 5-<10 years: 6.2, 1.3-28.7; ≥10 years: 5.6, 1.2-23.1), after adjusting for age, sex, BMI, diabetes complications, antidepressants and glucose-lowering treatment. Patients with <2 years diabetes duration also exhibited a significantly decreased mean mental component score (SF-36: <2 years: 50, 2-<5 years: 69). In type 2 diabetes with a short duration an increased depressive symptom score was observed.
目的在于探究 2 型糖尿病患者中糖尿病病程与抑郁症状之间的关联。DIAREG 登记研究利用了一项全国性普通医学实践数据库（德国疾病分析器）的数据，并通过前瞻性患者报告结局（PRO）数据进行了扩充，其中包括流行病学研究中心抑郁量表（CES-D：<16 与≥16）和 SF-36。采用多因素逻辑回归模型来探究糖尿病病程与 PRO 之间的关联。总体而言，108 家诊所共登记了 1807 名 2 型糖尿病患者。在 270 名（15%）完成完整 PRO 采集的患者中，与不完整数据患者（p≥0.05）相比，其年龄、性别、体重指数、HbA1c、糖尿病病程和治疗情况相似。与病程较短的患者（参考：<2 年）相比，病程较长的患者（CES-D<16：66%）出现抑郁症状（CES-D<16）的可能性显著降低（OR，95%CI：2-<5 年：5.9，1.2-29.6；5-<10 年：6.2，1.3-28.7；≥10 年：5.6，1.2-23.1），校正年龄、性别、BMI、糖尿病并发症、抗抑郁药和降糖治疗因素后仍具有统计学意义。病程<2 年的患者的 SF-36 心理成分评分也显著降低（<2 年：50，2-<5 年：69）。在病程较短的 2 型糖尿病患者中，抑郁症状评分有所升高。
