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系统性红斑狼疮患者荨麻疹性血管炎后获得性皮肤松弛症

Cutis Laxa Acquisita After Urticarial Vasculitis in SLE Patients.

作者信息

Golisch Kimberly B, Gottesman Silvija P, Ferrer Patricia, Culpepper Keliegh S

机构信息

University of Arizona College of Medicine, Tucson, AZ.

Ackerman Academy of Dermatopathology, New York, NY.

出版信息

Am J Dermatopathol. 2018 Jun;40(6):433-437. doi: 10.1097/DAD.0000000000001084.

Abstract

Cutis laxa is a rare connective tissue disease involving damage to dermal elastic fibers creating a clinical appearance of loose, sagging skin. The condition can be either acquired or genetic. Autoimmune diseases, neoplasms, infections, and medications have been proposed as the cause of, or in association with, the acquired form. In nearly 50% of cases, erythematous plaques present before the onset of cutis laxa. Separately, urticarial vasculitis and systemic lupus erythematosus have been linked to cutis laxa acquisita. Our case is the first in the literature documenting a coexistence of cutis laxa acquisita, hypocomplementemic urticarial vasculitis, and systemic lupus erythematosus.

摘要

皮肤松弛症是一种罕见的结缔组织疾病,涉及真皮弹性纤维受损,导致皮肤出现松弛、下垂的临床表现。该病可后天获得或由遗传引起。自身免疫性疾病、肿瘤、感染和药物已被认为是后天获得性皮肤松弛症的病因或与之相关。在近50%的病例中,红斑斑块在皮肤松弛症发作前出现。另外,荨麻疹性血管炎和系统性红斑狼疮与后天获得性皮肤松弛症有关。我们的病例是文献中首例记录后天获得性皮肤松弛症、低补体血症性荨麻疹性血管炎和系统性红斑狼疮共存的病例。

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