McCarty M J, Davidson J M, Cardone J S, Anderson L L
Hematology/Oncology Service, Womack Army Medical Center, Fort Bragg, North Carolina, USA.
Cutis. 1996 Apr;57(4):267-70.
Cutis laxa acquisita is a rare disorder that affects collagen and elastin metabolism. The cause is unknown. Characteristic features include sagging and laxity of the skin, as well as involvement of the lungs, heart, gastrointestinal system, and urogenital tract. Three cases of cutis laxa acquisita have been reported in association with multiple myeloma. Due to the rarity of these disorders, a linkage has been postulated. The clinical and histologic data from the fourth case of cutis laxa acquisita associated with multiple myeloma were compared to the three other cases previously reported in the literature. The relationship between acquired cutis laxa and multiple myeloma is unclear, with only one case revealing possible immune-mediated elastin destruction via IgG immunoglobulin bound to dermal elastin fibers on immunofluoresence examination. No pattern in the clinical courses of the disorder can be seen on review of the four cases with coincident disease. We hypothesize that cutis laxa acquisita represents a paraneoplastic process of multiple myeloma, given the rarity of these diseases. Further investigation is necessary to determine the underlying linkage between these disorders. We suggest that serum and urine protein electrophoresis results be obtained in patients presenting with cutis laxa acquisita to screen for multiple myeloma given this association.
获得性皮肤松弛症是一种罕见的疾病，会影响胶原蛋白和弹性蛋白的代谢。病因不明。其特征性表现包括皮肤松弛下垂，以及肺部、心脏、胃肠道系统和泌尿生殖道受累。已有三例获得性皮肤松弛症与多发性骨髓瘤相关的报道。由于这些疾病罕见，有人推测它们之间存在联系。将第四例与多发性骨髓瘤相关的获得性皮肤松弛症的临床和组织学数据与文献中先前报道的其他三例进行了比较。获得性皮肤松弛症与多发性骨髓瘤之间的关系尚不清楚，只有一例在免疫荧光检查中显示通过与真皮弹性纤维结合的IgG免疫球蛋白可能存在免疫介导的弹性蛋白破坏。回顾这四例合并疾病的病例，未发现该疾病临床病程中的规律。鉴于这些疾病的罕见性，我们推测获得性皮肤松弛症代表多发性骨髓瘤的一种副肿瘤性过程。有必要进一步研究以确定这些疾病之间的潜在联系。鉴于这种关联，我们建议对患有获得性皮肤松弛症的患者进行血清和尿蛋白电泳检测，以筛查多发性骨髓瘤。
