Kreuz André C, de Moraes Carlos G, Hatanaka Marcelo, Oyamada Maria K, Monteiro Mario L R
Department of Ophthalmology and Otolaryngology, University of São Paulo Medical School (USP), São Paulo, Brazil.
Department of Ophthalmology, Columbia University Medical Center, New York, NY.
J Glaucoma. 2018 Feb;27(2):121-132. doi: 10.1097/IJG.0000000000000857.
To evaluate the ability of macular and multifocal (mf) pattern electroretinogram (PERG) to differentiate preperimetric glaucoma (PG) and glaucoma with hemifield loss (GHL) from controls, to compare the discrimination ability of PERG and fourier-domain optical coherence tomography (FD-OCT), and to assess the relationship between measurements.
Standard automated perimetry, steady-state and transient PERG and mfPERG measurements were obtained from PG (n=14, 24 eyes), GHL (n=5, 7 eyes), and controls (n=19, 22 eyes). Circumpapillary retinal nerve fiber layer (cpRNFL), full-thickness macula, and segmented macular layer thicknesses on FD-OCT were investigated. Measurements were compared using mixed effects linear models. The relationships between measurements and the diagnostic performance of each technology were assessed.
Compared with controls, average P50 peak time transient PERG responses were reduced in PG and GHL, whereas average latency and amplitude steady-state and mfPERG responses were abnormal only in GHL. cpRNFL and macular thickness measurements in PG and GHL differed significantly from controls. A significant relationship was found between PERG and most FD-OCT or SAP parameters. Partial least squares discriminant analysis revealed that OCT parameters, along with mfPERG and transient PERG parameters had similar ability to discriminate PG and GHL from healthy controls.
PERG and OCT parameters may be abnormal, with significant correlations between measurements, in PG eyes. Both technologies may be useful for detection of early glaucoma.
评估黄斑和多焦（mf）图形视网膜电图（PERG）区分视野缺损前青光眼（PG）和伴有半视野缺损青光眼（GHL）与对照组的能力，比较PERG和傅里叶域光学相干断层扫描（FD - OCT）的鉴别能力，并评估测量值之间的关系。
对PG组（n = 14，24只眼）、GHL组（n = 5，7只眼）和对照组（n = 19，22只眼）进行标准自动视野检查、稳态和瞬态PERG以及mfPERG测量。研究了FD - OCT上的视乳头周围视网膜神经纤维层（cpRNFL）、全层黄斑和黄斑分层厚度。使用混合效应线性模型比较测量值。评估了测量值与每种技术的诊断性能之间的关系。
与对照组相比，PG组和GHL组的平均P50峰时瞬态PERG反应降低，而平均潜伏期和振幅稳态及mfPERG反应仅在GHL组异常。PG组和GHL组的cpRNFL和黄斑厚度测量值与对照组有显著差异。发现PERG与大多数FD - OCT或标准自动视野检查参数之间存在显著关系。偏最小二乘判别分析显示，OCT参数以及mfPERG和瞬态PERG参数具有相似的能力将PG和GHL与健康对照区分开来。
在PG眼中，PERG和OCT参数可能异常，测量值之间存在显著相关性。两种技术可能都有助于早期青光眼的检测。
