Huber S J, Paulson G W
Am J Psychiatry. 1985 Nov;142(11):1312-7. doi: 10.1176/ajp.142.11.1312.
The authors review the concept of subcortical dementia, specifically the dementia associated with Huntington's disease, Parkinson's disease, and progressive supranuclear palsy, all subcortical processes that involve deterioration of mental abilities. Subcortical dementia affords a unique opportunity to study the progressive memory loss associated with dementia because, in contrast to cortical dementias such as Alzheimer's disease, this relatively circumscribed syndrome does not involve dysfunction of language (aphasia) and perception (agnosia and apraxia). Research strategies are proposed to examine the concept of subcortical dementia, an entity that remains controversial and not well understood. The subcortical dementias may constitute a group of partially treatable forms of dementia.
作者回顾了皮质下痴呆的概念，特别是与亨廷顿舞蹈病、帕金森病和进行性核上性麻痹相关的痴呆，所有这些皮质下病变均涉及智力衰退。皮质下痴呆为研究与痴呆相关的进行性记忆丧失提供了独特的机会，因为与阿尔茨海默病等皮质性痴呆不同，这种相对局限的综合征不涉及语言功能障碍（失语症）和感知功能障碍（失认症和失用症）。本文提出了研究策略，以探讨皮质下痴呆这一仍具争议且尚未被充分理解的实体概念。皮质下痴呆可能构成一组部分可治疗的痴呆形式。
