克拉夫丁 A 和 B，两种从西沙软珊瑚 Clavularia viridis 中分离得到的新的三降-愈创木烷倍半萜。
Clavuridins A and B, two new trinor-guaiane sesquiterpenes isolated from the Xisha soft coral Clavularia viridis.
机构信息
College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China.
Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222002, China.
出版信息
Chin J Nat Med. 2017 Nov;15(11):855-859. doi: 10.1016/S1875-5364(18)30019-0.
In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B (1), and A (2), along with three known sesquiterpenes (3-5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3-5 were evaluated for their cytotoxic activity.
在本研究中，从西沙软珊瑚 Clavularia viridis 中分离得到了两种新的三降-愈创木烷倍半萜，命名为clavuridins B（1）和 A（2），以及三种已知的倍半萜（3-5）。基于光谱分析、Cu Kα 辐射的 X 射线衍射分析和与相关模型化合物的比较，确定了它们的结构和绝对构型。评估了化合物 1 和 3-5 的细胞毒性活性。
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