Komuro K, Mitsumori N, Iwamoto K, Murai R, Ishida T, Nagasaki Y, Hujii Y, Amano R, Yamazaki M, Nagayama A
Gan To Kagaku Ryoho. 1985 Nov;12(11):2222-4.
52-year-old female was weakened and bed-ridden by metastasis of gastric cancer to the chest and abdominal wall, and peritonitis carcinomatosa 2 years after gastrectomy. One week after administration of 5'-DFUR, 1200 mg/d, p.o., a clinical effect was seen. In 3 weeks metastatic lesions had diminished in size, ascites had decreased and the patient had regained her appetite and put on weight. She recovered sufficiently to be able to do some daily work. Pathological degeneration and necrosis of cancer cells were observed. Although she died 8 months after remission, 5'-DFUR was effective in improving her condition and prolonging her life.
一名52岁女性因胃癌转移至胸腹壁及胃癌切除术后2年发生癌性腹膜炎而身体虚弱、卧床不起。口服5'-DFUR,1200mg/d,用药1周后出现临床效果。3周内转移灶缩小,腹水减少,患者食欲恢复且体重增加。她恢复到足以能够做一些日常工作。观察到癌细胞发生病理退变和坏死。尽管她在病情缓解8个月后死亡,但5'-DFUR在改善其状况和延长其生命方面是有效的。