College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Institute of Immunology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310058, China.
Cancer Lett. 2018 Apr 10;419:27-29. doi: 10.1016/j.canlet.2018.01.008. Epub 2018 Jan 9.
Long noncoding RNAs (LncRNAs) are one of the emerging regulators which are involved in diverse biological processes. LncRNAs can participate in the regulation of gene expression via various ways in the cytoplasm and the nucleus. The function of the nuclear lncRNAs has been studied a lot. Recent studies have shown that the regulatory roles of cytoplasmic lncRNA, including membrane lipid associated lncRNA, which may open an unexplored mechanistic territory. LncRNA dysregulated expression represents a common event in pathogenesis of a variety of human genetic diseases including cancer. Lipid-associated lncRNA is capable of modulating critical cellular functions by directly interacting with phospholipids on the plasma membrane. Besides, it also could be a predictor for the poor prognosis of cancer. In this review, we sum up the roles of cytoplasmic lncRNA, especially lipid-associated lncRNA in cancer.
长链非编码 RNA（lncRNA）是新兴的调控因子之一，参与多种生物学过程。lncRNA 可以通过细胞质和细胞核中的多种方式参与基因表达的调控。核 lncRNA 的功能已得到广泛研究。最近的研究表明，细胞质 lncRNA 的调节作用，包括与膜脂质相关的 lncRNA，可能开辟了一个尚未探索的机制领域。lncRNA 表达失调是多种人类遗传疾病（包括癌症）发病机制中的常见事件。脂质相关 lncRNA 通过与质膜上的磷脂直接相互作用，能够调节关键的细胞功能。此外，它还可能是癌症预后不良的预测因子。在这篇综述中，我们总结了细胞质 lncRNA，特别是与脂质相关的 lncRNA 在癌症中的作用。
