Xing Zhen, Park Peter K, Lin Chunru, Yang Liuqing
a Department of Molecular and Cellular Oncology; MD Anderson Cancer Center; The University of Texas ; Houston , TX , USA.
RNA Biol. 2015;12(7):681-9. doi: 10.1080/15476286.2015.1053687.
Long noncoding RNAs (lncRNAs) are dysregulated in many cancer types and are believed to play crucial roles in regulating several hallmarks of cancer biology. Currently, most studies support the concept that lncRNAs are involved in either transcriptional or post-transcriptional processes via binding/targeting epigenetic modifiers or hRNP complexes. The discovery of new biological functions of lncRNA and novel RNA binding proteins suggests that lncRNAs may be implicated in a broad spectrum of biological processes such as signal transduction, allosteric regulation of cytoplasmic enzymatic activities, among other potential processes. In a recent report that we have made, based on open-ended lncRNA pulldown technology and a series of systematic analyses, we suggest that lncRNAs also play critical roles in the regulation of noncanonical Hedgehog/GLI 2 signal transduction pathways in cancer cells, which further broadens the scope of known lncRNA functions and aids in the discovery and design of more effective and evidence-based therapeutic targets for the treatment of human cancers and other diseases.
长链非编码RNA（lncRNAs）在多种癌症类型中表达失调，被认为在调节癌症生物学的多个标志方面发挥着关键作用。目前，大多数研究支持这样的观点，即lncRNAs通过结合/靶向表观遗传修饰因子或异质性核糖核蛋白复合物参与转录或转录后过程。lncRNA新生物学功能和新型RNA结合蛋白的发现表明，lncRNAs可能涉及广泛的生物学过程，如信号转导、细胞质酶活性的变构调节以及其他潜在过程。在我们最近发表的一篇报告中，基于开放式lncRNA下拉技术和一系列系统分析，我们表明lncRNAs在癌细胞中非经典刺猬信号通路/GLI 2信号转导途径的调节中也发挥着关键作用，这进一步拓宽了已知lncRNA功能的范围，并有助于发现和设计更有效且基于证据的治疗靶点，用于治疗人类癌症和其他疾病。
