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内分泌肿瘤中的基因突变。

gene mutations in endocrine tumors.

机构信息

Division of NeurosurgeryDepartment of Surgery, St. Michael's Hospital, Toronto, Ontario, Canada.

Division of PathologyDepartment of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, Canada

出版信息

Endocr Relat Cancer. 2018 Mar;25(3):R197-R208. doi: 10.1530/ERC-17-0509. Epub 2018 Jan 12.

DOI:10.1530/ERC-17-0509
PMID:29330195
Abstract

In this review, the importance of the gene in the function of endocrine cells is discussed. There is conclusive evidence that mutations play a crucial role in the development, progression, cell proliferation, therapeutic responsiveness and behavior of several endocrine tumors. We review the literature of gene mutations in thyroid, parathyroid, pituitary, pineal gland, endocrine pancreas, paragangliomas, medullary, adrenocortical, ovarian and testicular tumors. Although significant progress has been made during the last few years, much more work is needed to fully understand the significance of mutations.

摘要

在这篇综述中，讨论了 基因在内分泌细胞功能中的重要性。有确凿的证据表明， 基因突变在几种内分泌肿瘤的发生、发展、细胞增殖、治疗反应和行为中起着关键作用。我们回顾了甲状腺、甲状旁腺、垂体、松果体、内分泌胰腺、副神经节瘤、神经内分泌肿瘤、肾上腺皮质、卵巢和睾丸肿瘤中 基因突变的文献。尽管在过去几年中取得了重大进展，但仍需要更多的工作来充分理解 基因突变的意义。

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