Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany; and.
Department of Internal Medicine and Rheumatology, Dr. I. Cantacuzino Clinical Hospital, Carol Davila University of Medicine and Pharmacy, Bucharest 020475, Romania.
J Immunol. 2018 Feb 15;200(4):1249-1254. doi: 10.4049/jimmunol.1700596. Epub 2018 Jan 12.
Innate lymphoid cells (ILC) have a high potency for cytokine production independent of specific Ag stimulation. Imbalance of ILC subsets may influence cytokine production in humans and hence be associated with the development of inflammatory disease. Evidence for an imbalance of ILC homeostasis in human disease, however, is very limited to date. In this study we show that psoriatic arthritis (PsA), a severe disease of the joints depending on the activation of the IL-23/IL-17 pathway, is characterized by a skewed ILC homeostasis. Circulating ILC3s as potent source of IL-17/IL-22 were elevated in active PsA, whereas ILC2s, which produce proresolving cytokines, were decreased. The ILC2/ILC3 ratio was significantly correlated with clinical disease activity scores and the presence of imaging signs of joint inflammation and bone damage. Multivariable analysis showed that a high ILC2/ILC3 ratio is associated with remission in PsA, suggesting that specific alterations of ILC homeostasis control disease activity in PsA.
固有淋巴细胞 (ILC) 具有在不受特定抗原刺激的情况下产生细胞因子的高能力。ILC 亚群的失衡可能会影响人类的细胞因子产生，因此与炎症性疾病的发展有关。然而，迄今为止，关于人类疾病中 ILC 稳态失衡的证据非常有限。在这项研究中，我们表明，银屑病关节炎 (PsA) 是一种严重的关节疾病，依赖于 IL-23/IL-17 途径的激活，其特征是 ILC 稳态发生偏斜。循环 ILC3 作为强有力的 IL-17/IL-22 来源在活动性 PsA 中升高，而产生促解决细胞因子的 ILC2 则减少。ILC2/ILC3 比值与临床疾病活动评分以及关节炎症和骨损伤的影像学征象显著相关。多变量分析表明，高 ILC2/ILC3 比值与 PsA 的缓解相关，提示 ILC 稳态的特定改变控制着 PsA 的疾病活动。
