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肥胖症手术术后严重并发症风险预测模型。

Risk Prediction Model for Severe Postoperative Complication in Bariatric Surgery.

机构信息

Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Department of Surgery, Örebro University Hospital, SE-70185, Örebro, Sweden.

出版信息

Obes Surg. 2018 Jul;28(7):1869-1875. doi: 10.1007/s11695-017-3099-2.

Abstract

BACKGROUND

Factors associated with risk for adverse outcome are important considerations in the preoperative assessment of patients for bariatric surgery. As yet, prediction models based on preoperative risk factors have not been able to predict adverse outcome sufficiently.

OBJECTIVE

This study aimed to identify preoperative risk factors and to construct a risk prediction model based on these.

METHODS

Patients who underwent a bariatric surgical procedure in Sweden between 2010 and 2014 were identified from the Scandinavian Obesity Surgery Registry (SOReg). Associations between preoperative potential risk factors and severe postoperative complications were analysed using a logistic regression model. A multivariate model for risk prediction was created and validated in the SOReg for patients who underwent bariatric surgery in Sweden, 2015.

RESULTS

Revision surgery (standardized OR 1.19, 95% confidence interval (CI) 1.14-0.24, p < 0.001), age (standardized OR 1.10, 95%CI 1.03-1.17, p = 0.007), low body mass index (standardized OR 0.89, 95%CI 0.82-0.98, p = 0.012), operation year (standardized OR 0.91, 95%CI 0.85-0.97, p = 0.003), waist circumference (standardized OR 1.09, 95%CI 1.00-1.19, p = 0.059), and dyspepsia/GERD (standardized OR 1.08, 95%CI 1.02-1.15, p = 0.007) were all associated with risk for severe postoperative complication and were included in the risk prediction model. Despite high specificity, the sensitivity of the model was low.

CONCLUSION

Revision surgery, high age, low BMI, large waist circumference, and dyspepsia/GERD were associated with an increased risk for severe postoperative complication. The prediction model based on these factors, however, had a sensitivity that was too low to predict risk in the individual patient case.

摘要

背景

与不良结局相关的因素是肥胖症手术患者术前评估的重要考虑因素。然而,基于术前危险因素的预测模型还不能充分预测不良结局。

目的

本研究旨在确定术前危险因素,并基于这些因素构建风险预测模型。

方法

从斯堪的纳维亚肥胖症手术登记处(SOReg)中确定了 2010 年至 2014 年间在瑞典接受肥胖症手术的患者。使用逻辑回归模型分析术前潜在危险因素与严重术后并发症之间的关联。为瑞典 2015 年接受肥胖症手术的患者创建了一个多变量风险预测模型,并在 SOReg 中进行了验证。

结果

翻修手术(标准化比值 1.19,95%置信区间(CI)1.14-0.24,p<0.001)、年龄(标准化比值 1.10,95%CI 1.03-1.17,p=0.007)、低体重指数(标准化比值 0.89,95%CI 0.82-0.98,p=0.012)、手术年份(标准化比值 0.91,95%CI 0.85-0.97,p=0.003)、腰围(标准化比值 1.09,95%CI 1.00-1.19,p=0.059)和消化不良/胃食管反流病(标准化比值 1.08,95%CI 1.02-1.15,p=0.007)均与严重术后并发症的风险相关,并纳入风险预测模型。尽管特异性高,但该模型的灵敏度较低。

结论

翻修手术、高龄、低 BMI、大腰围和消化不良/胃食管反流病与严重术后并发症风险增加相关。然而,基于这些因素的预测模型的灵敏度太低,无法预测个体患者的风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2523/6018582/a29dbba0b8a7/11695_2017_3099_Fig1_HTML.jpg

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