Schmalzing M, Tony H-P, Knop S
Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Oberdürrbacher Straße 6, 97080, Würzburg, Deutschland.
Z Rheumatol. 2017 Oct;76(Suppl 2):33-37. doi: 10.1007/s00393-017-0335-z.
In rheumatological practice monoclonal gammopathy of undetermined significance (MGUS) is a common incidental finding. Several rheumatic inflammatory diseases are known to have an elevated risk of MGUS, which can evolve into multiple myeloma or other lymphatic malignancies. The relevant definitions of disease entities are described, as well as algorithms for further diagnostic work-up and follow-up for monoclonal gammopathy, depending on the risk of progression. Therapeutic strategies against multiple myeloma are presented. Some of these therapeutic modalities could play a future role in treating plasma cell-dominated autoimmune diseases.
在风湿病学实践中，意义未明的单克隆丙种球蛋白病（MGUS）是一种常见的偶然发现。已知几种风湿性炎症性疾病发生MGUS的风险升高，MGUS可演变为多发性骨髓瘤或其他淋巴系统恶性肿瘤。本文描述了疾病实体的相关定义，以及根据进展风险对单克隆丙种球蛋白病进行进一步诊断检查和随访的算法。介绍了针对多发性骨髓瘤的治疗策略。其中一些治疗方式可能在治疗以浆细胞为主的自身免疫性疾病中发挥未来作用。
