Prabhakar Uday, Singh Anup
Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, India.
J Ayub Med Coll Abbottabad. 2017 Oct-Dec;29(4):692-693.
Acute febrile illness is a common entity in tropics and often is challenging due a host of pathogenic bacteria, viruses and fungi. Extensive work up is required for better management. Rickettsiosis is uncommon and hence comes lower down in the differentials of multiorgan failure being superseded by the more common diseases as malaria, enteric fever and Dengue. We document a case of young male presenting with high grade fever, multiorgan dysfunction (hepatic, renal, neurological and respiratory involvement), conjunctival suffusion, retiform rash and without lymphadenopathy. The diagnosis was further challenging because the rashes appeared late at 8th day in the course of illness, unlike the typical disease where rashes come on early in day 3-6 of the disease. Patient responded to timely treatment with doxycycline. Thus, a high index of suspicion is needed to diagnose Rickettsiosis in geographical areas apparently free of the disease.
急性发热性疾病在热带地区很常见,由于存在大量致病细菌、病毒和真菌,往往具有挑战性。为了更好地进行治疗,需要进行全面的检查。立克次体病并不常见,因此在多器官功能衰竭的鉴别诊断中排名靠后,被更常见的疾病如疟疾、伤寒和登革热所取代。我们记录了一例年轻男性病例,该患者出现高热、多器官功能障碍(肝脏、肾脏、神经和呼吸系统受累)、结膜充血、网状皮疹且无淋巴结肿大。诊断进一步具有挑战性,因为皮疹在病程的第8天才出现,这与典型疾病不同,典型疾病的皮疹在病程的第3 - 6天早期出现。患者对强力霉素的及时治疗有反应。因此,在明显没有这种疾病的地理区域,诊断立克次体病需要高度的怀疑指数。