Wan Ab Naim Wan Naimah, Ganesan Poo Balan, Sun Zhonghua, Lei Jing, Jansen Shirley, Hashim Shahrul Amry, Ho Teik Kok, Lim Einly
Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Int J Numer Method Biomed Eng. 2018 May;34(5):e2961. doi: 10.1002/cnm.2961. Epub 2018 Mar 5.
Endovascular stent graft repair has become a common treatment for complicated Stanford type B aortic dissection to restore true lumen flow and induce false lumen thrombosis. Using computational fluid dynamics, this study reports the differences in flow patterns and wall shear stress distribution in complicated Stanford type B aortic dissection patients after endovascular stent graft repair. Five patients were included in this study: 2 have more than 80% false lumen thrombosis (group 1), while 3 others had less than 80% false lumen thrombosis (group 2) within 1 year following endovascular repair. Group 1 patients had concentrated re-entry tears around the abdominal branches only, while group 2 patients had re-entry tears that spread along the dissection line. Blood flow inside the false lumen which affected thrombus formation increased with the number of re-entry tears and when only small amounts of blood that entered the false lumen exited through the branches. In those cases where dissection extended below the abdominal branches (group 2), patients with fewer re-entry tears and longer distance between the tears had low wall shear stress contributing to thrombosis. This work provides an insight into predicting the development of complete or incomplete false lumen thrombosis and has implications for patient selection for treatment.
血管内支架植入修复术已成为治疗复杂Stanford B型主动脉夹层的常用方法,以恢复真腔血流并促使假腔血栓形成。本研究采用计算流体动力学方法,报告了复杂Stanford B型主动脉夹层患者血管内支架植入修复术后血流模式和壁面切应力分布的差异。本研究纳入了5例患者:2例在血管内修复术后1年内假腔血栓形成超过80%(第1组),另外3例假腔血栓形成少于80%(第2组)。第1组患者仅在腹部分支周围有集中的再入口撕裂,而第2组患者的再入口撕裂沿剥离线扩散。影响血栓形成的假腔内血流随再入口撕裂数量的增加而增加,且当仅有少量进入假腔的血液通过分支流出时也是如此。在剥离延伸至腹部分支以下的病例(第2组)中,再入口撕裂较少且撕裂之间距离较长的患者壁面切应力较低,这有助于血栓形成。这项工作为预测完全或不完全假腔血栓形成的发展提供了见解,并对治疗的患者选择具有启示意义。