Kokubu M, Shimada M, Suzuki N, Kubota Y, Shinya N
Bull Tokyo Med Dent Univ. 1985 Jun;32(2):49-55.
The concentrations of human immunoreactive beta-endorphin-like substances in plasma were measured as a means of determining the effects of general anesthesia and surgical stress on the endogenous morphine-like substances. Sixty-nine adult patients and 44 pediatric patients who had undergone oral surgery in general anesthesia were the subjects of this study. In comparison to the control values, the results of this study showed an increase of beta-endorphin concentration in the plasma during anesthesia and surgery. The increase was particularly significant in the patients who had relatively a major surgical stress and in those patients showing a weak anesthetic action, while the patients with relatively a minor surgical stress or strong anesthetic action showed a small increase. From these findings, it seems proper to assume that the secretion of beta-endorphin in the plasma is accelerated by general anesthesia and surgical stress than to assume that the amount of beta-endorphin in the plasma is increased by the administration of anesthetic agents.
作为确定全身麻醉和手术应激对内源性吗啡样物质影响的一种手段，对血浆中人类免疫反应性β-内啡肽样物质的浓度进行了测量。69名成年患者和44名接受全身麻醉下口腔手术的儿科患者是本研究的对象。与对照值相比，本研究结果显示，麻醉和手术期间血浆中β-内啡肽浓度升高。在手术应激相对较大的患者以及麻醉作用较弱的患者中，这种升高尤为显著，而手术应激相对较小或麻醉作用较强的患者升高幅度较小。从这些发现来看，似乎可以合理推测，全身麻醉和手术应激会加速血浆中β-内啡肽的分泌，而不是认为麻醉剂的使用会增加血浆中β-内啡肽的量。
