Department of Human Sciences, European University, Rome, Italy.
Psychopathology. 2018;51(1):16-23. doi: 10.1159/000485517. Epub 2018 Jan 13.
We investigated default mode network (DMN) electroencephalography (EEG) functional connectivity differences between individuals with self-reported high mentalization capability and low psychopathological symptoms, versus participants with mentalization impairments and high psychopathological symptoms.
Forty-nine students (35 women) with a mean age of 22.92 ± 2.53 years were administered the Mentalization Questionnaire (MZQ) and the Symptom Checklist-90-Revised. Five minutes of EEG during resting state were also recorded for each participant. DMN functional connectivity analyses were conducted by means of the exact Low Resolution Electric Tomography software (eLORETA).
Compared to the individuals with high mentalization capability and lower self-reported psychopathological symptoms, participants with mentalization impairments and high psychopathological symptoms showed a decrease of EEG beta connectivity between: (i) the right and left medial frontal lobe, and (ii) the left medial frontal lobe and the right anterior cingulate cortex. Furthermore, while MZQ total score was positively associated with DMN network connections (i.e., right and left medial frontal lobes), several psychopathological symptoms (i.e., interpersonal sensitivity, depression, and psychoticism) were negatively associated with DMN connectivity.
Our results may reflect a top-down emotion regulation deficit which is associated with both internalizing and externalizing behavior problems.
我们研究了自我报告的高心理化能力和低精神病理症状的个体与心理化受损和高精神病理症状的个体之间默认模式网络（DMN）脑电图（EEG）功能连接的差异。
49 名学生（35 名女性），平均年龄为 22.92 ± 2.53 岁，接受了心理化问卷（MZQ）和症状清单-90-修订版的评估。每位参与者还记录了 5 分钟的静息状态脑电图。DMN 功能连接分析采用精确低分辨率电层析成像软件（eLORETA）进行。
与高心理化能力和较低自我报告精神病理症状的个体相比，心理化受损和高精神病理症状的个体在：（i）右侧和左侧内侧额叶之间，以及（ii）左侧内侧额叶和右侧前扣带皮质之间的 EEG 贝塔连接减少。此外，MZQ 总分与 DMN 网络连接呈正相关（即右侧和左侧内侧额叶），而一些精神病理症状（即人际敏感、抑郁和精神病态）与 DMN 连接呈负相关。
我们的结果可能反映了一种自上而下的情绪调节缺陷，它与内化和外化行为问题都有关。
