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血小板聚集活性降低所致难治性出血的骨髓增生异常综合征

[Myelodysplastic syndrome with refractory hemorrhage due to reduced platelet aggregation activity].

作者信息

Tanaka Tomoyuki, Kozakai Takashi, Kitajima Toshiki, Fuse Kyoko, Kobayashi Hironori, Ushiki Takashi, Shibazaki Yasuhiko, Moriyama Masato, Takizawa Jun, Sone Hirohito, Fuse Ichiro, Masuko Masayoshi

机构信息

Department of Hematology, Sado General Hospital.

Department of Hematology, Endocrinology and Metabolism, Niigata University Faculty of Medicine.

出版信息

Rinsho Ketsueki. 2017;58(12):2402-2405. doi: 10.11406/rinketsu.58.2402.

DOI:10.11406/rinketsu.58.2402
PMID:29332874
Abstract

A 75-year-old woman suffered a cat bite 10 months after myelodysplastic syndrome (MDS) diagnosis. She visited our hospital because the internal bleeding of the wound did not improve. Although the wound was treated, the bleeding did not stop. She was hospitalized for emergency medical treatment because the bleeding volume exceeded 200 ml. Although her platelet count was normal, the platelet function test showed a decrease in collagen and arachidonic acid aggregation. After platelet transfusion, her bleeding stopped. Patients with MDS may potentially have platelet dysfunction. In the case of bleeding without thrombocytopenia, a platelet function test should be performed and treatment intervention, such as platelet transfusion, should be considered.

摘要

一名75岁女性在骨髓增生异常综合征(MDS)诊断10个月后被猫咬伤。她因伤口内出血未改善前来我院就诊。尽管伤口得到了处理,但出血仍未停止。由于出血量超过200毫升,她因紧急医疗而住院。尽管她的血小板计数正常,但血小板功能测试显示胶原蛋白和花生四烯酸聚集减少。输注血小板后,她的出血停止。MDS患者可能存在血小板功能障碍。在无血小板减少而出血的情况下,应进行血小板功能测试,并应考虑进行诸如血小板输注等治疗干预。

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