Brody A S, Sorette M P, Gooding C A, Listerud J, Clark M R, Mentzer W C, Brasch R C, James T L
Invest Radiol. 1985 Sep;20(6):560-6. doi: 10.1097/00004424-198509000-00004.
Deoxygenated sickle erythrocytes in static suspension align perpendicular to a magnetic field. To assess the importance of this observation to MRI of sickle-cell disease, an in vitro flow apparatus was devised and the orientation of sickle erythrocytes flowing through a 0.38 T magnetic field was investigated. We showed a significant perpendicular alignment of fully deoxygenated sickle erythrocytes flowing at 3 to 4 mm/minute (P less than .001). These results suggest that deoxygenated erythrocytes in a sickle-cell patient could orient perpendicular to a magnetic field, and therefore that MRI of such patients could possibly result in worsening of vaso-occlusive complications. Further studies are needed to assess the possible hazards of MRI of sickle-cell disease, especially at high field strengths.
静态悬浮状态下的脱氧镰状红细胞会垂直于磁场排列。为评估这一观察结果对镰状细胞病磁共振成像（MRI）的重要性，设计了一种体外流动装置，并研究了流经0.38 T磁场的镰状红细胞的取向。我们发现，以3至4毫米/分钟流速流动的完全脱氧镰状红细胞存在显著的垂直排列（P小于0.001）。这些结果表明，镰状细胞病患者体内的脱氧红细胞可能会垂直于磁场取向，因此对此类患者进行MRI检查可能会导致血管闭塞性并发症恶化。需要进一步研究以评估镰状细胞病MRI检查可能存在的风险，尤其是在高场强情况下。
