Division of Neonatal Medicine, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Division of Neonatology, Stead Family Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
Acta Paediatr. 2018 Aug;107(8):1339-1344. doi: 10.1111/apa.14219. Epub 2018 Feb 5.
To characterise the relationship between bronchopulmonary dysplasia (BPD) severity and cognition in the post-surfactant era.
This was a single-centre retrospective analysis of a cohort of infants born 2009-2012. Inclusion criteria were as follows: admission within 48 hours of birth, gestational age 22-0/7-31-6/7 weeks, birthweight 400-1500 g and Bayley Scales of Infant and Toddler Development-III testing at 18-26 months corrected age. Infants (n = 151) were classified by BPD severity with the NIH Workshop definition. Generalised linear modelling and multivariate logistic regression were performed.
Bayley cognitive score was not associated with BPD severity in univariate (p = 0.053) or multivariate (p = 0.503) analysis. About 27% of infants with no/mild BPD, 33% of infants with moderate BPD and 40% of infants with severe BPD had a cognitive score <85. There was no difference in the odds of cognitive score <85 based on BPD severity in univariate (p = 0.485) or multivariate analysis (p = 0.225). All infants with cognitive score <70 had severe BPD, although the association between cognitive score <70 and BPD severity was not significant.
We found no independent effect of BPD severity level on cognition. The likelihood of a cognitive score <85 was not associated with BPD severity.
描述表面活性物质时代后支气管肺发育不良（BPD）严重程度与认知之间的关系。
这是一项对 2009-2012 年出生的婴儿队列进行的单中心回顾性分析。纳入标准如下：出生后 48 小时内入院，胎龄 22-0/7-31-6/7 周，出生体重 400-1500 克，18-26 个月校正年龄时进行贝利婴幼儿发育量表第三版测试。根据 NIH 研讨会的定义，将婴儿（n=151）分为 BPD 严重程度。进行广义线性模型和多变量逻辑回归分析。
在单变量（p=0.053）或多变量（p=0.503）分析中，贝利认知评分与 BPD 严重程度无关。大约 27%的无/轻度 BPD 婴儿、33%的中度 BPD 婴儿和 40%的重度 BPD 婴儿的认知评分<85。在单变量（p=0.485）或多变量分析（p=0.225）中，根据 BPD 严重程度，认知评分<85 的可能性没有差异。所有认知评分<70 的婴儿都有严重的 BPD，尽管认知评分<70 与 BPD 严重程度之间的关联没有统计学意义。
我们没有发现 BPD 严重程度水平对认知有独立影响。认知评分<85 的可能性与 BPD 严重程度无关。
