快速体重增长轨迹是否能改善支气管肺发育不良极低出生体重儿的神经发育结局？
Does faster weight trajectory lead to improved neurodevelopmental outcomes in ELBW infants with bronchopulmonary dysplasia?
机构信息
Division of Neonatology, Oregon Health & Science University, Portland, OR, USA.
Vermont Oxford Network, Burlington, VT, USA.
出版信息
J Perinatol. 2024 Feb;44(2):301-306. doi: 10.1038/s41372-023-01808-z. Epub 2023 Oct 28.
OBJECTIVE
Examine the relationship between weight trajectory and 2-year neurodevelopmental outcomes for extremely low birthweight (ELBW) infants with BPD.
STUDY DESIGN
Secondary analysis of infants born from 2010 to 2019. The predictor was BPD severity and the outcome was neurodevelopmental impairment, defined as any Bayley Scales of Infant Development (BSID) III score <70 at 24 months' corrected age. Repeated measures logistic regression was performed.
RESULTS
In total, 5042 infants were included. Faster weight trajectory was significantly associated with a decreased probability of having at least one BSID III score <70 for infants with grade 1-2 BPD (p < 0.0001) and an increased probability of at least one BSID III score <70 for infants with grade 3 BPD (p < 0.009). There was no significant association between weight trajectory and BSID III score <70 for infants with grade 0 BPD.
CONCLUSION
The association between postnatal weight trajectory and neurodevelopmental outcome in this study differs by BPD severity.
目的
研究患有支气管肺发育不良（BPD）的极低出生体重（ELBW）儿体重变化轨迹与 2 年神经发育结局的关系。
研究设计
对 2010 年至 2019 年出生的婴儿进行二次分析。预测因子为 BPD 严重程度，结局为神经发育障碍，定义为校正 24 月龄后任何贝利婴幼儿发展量表（BSID）III 评分＜70。采用重复测量 logistic 回归分析。
结果
共纳入 5042 例婴儿。对于 BPD 1-2 级的婴儿，体重变化轨迹越快，BSID III 评分＜70 的可能性越低（p＜0.0001）；对于 BPD 3 级的婴儿，BSID III 评分＜70 的可能性越高（p＜0.009）。BPD 0 级婴儿的体重变化轨迹与 BSID III 评分＜70 之间无显著相关性。
结论
本研究中，出生后体重变化轨迹与神经发育结局的关系因 BPD 严重程度而异。
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