2014年至2016年口腔医院药品不良反应回顾性分析
[Retrospective analysis of adverse drug reactions in stomatology hospital from 2014 to 2016].
作者信息
Jia Li, Jianli Wang, Ke Zhao, Shaofeng Zhao
机构信息
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & State Institute of Drug Clinical Trial, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pharmacy, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
出版信息
Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Dec 1;35(6):625-628. doi: 10.7518/hxkq.2017.06.012.
OBJECTIVE
This study aims to investigate the characteristics and general rules of adverse drug reactions (ADR) in a 3A-grade stomatology hospital for safe and rational drug use in clinical stomatology.
METHODS
We retrospectively analyzed 52 ADR cases (1∶1.36, males∶females) reported in the West China Hospital of Stomatology of Sichuan University from 2014 to 2016 in terms of gender and age distributions, drug categories, and clinical manifestations.
RESULTS
Eight kinds of drugs and antibiotics were predominately used [24 cases, 46.15% (24/52)], followed by nutrition drugs and antitumor drugs. Cephalosporin was the leading antibiotic drug associated with ADR [20 cases, 83.33% (20/24)]. Intravenous infusion was the most common route of drug administration [49 cases, 94.23% (49/52)]. The most common manifestations of the ADR were damages of the skin and its appendages and lesions of the digestive and nervous systems.
CONCLUSIONS
Strengthening the ADR monitoring system and further management should be implemented to alleviate ADR in stomatology hospitals.
目的
本研究旨在探讨某三甲口腔医院药品不良反应（ADR）的特点及一般规律，以促进口腔临床用药的安全与合理。
方法
回顾性分析四川大学华西口腔医院2014年至2016年上报的52例ADR病例（男女比例为1∶1.36）的性别、年龄分布、药品类别及临床表现。
结果
主要使用的药品及抗生素有8类[24例，占46.15%（24/52）]，其次为营养药和抗肿瘤药。头孢菌素类是导致ADR的主要抗生素[20例，占83.33%（20/24）]。静脉滴注是最常见的给药途径[49例，占94.23%（49/52）]。ADR最常见的表现为皮肤及其附属器损害以及消化系统和神经系统损害。
结论
应加强ADR监测体系并进一步实施管理，以减轻口腔医院的ADR。
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