Xiaotong Wang, Nanquan Rao, Jing Xie, Yuming Zhao, Lihong Ge
Dept. of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Dec 1;35(6):629-635. doi: 10.7518/hxkq.2017.06.013.
This study aims to assess the remineralization effect of casein phosphopeptide (CPP)-amorphous calcium phosphate (ACP) on enamel demineralization by performing system review of randomized controlled trials (RCT) involving the treatment of enamel demineralization with CPP-ACP.
METHODS: The study was developed based on the Cochrane handbook for systematic reviews of interventions (Version 5.1.0) and included the following: search strategy, selection criteria, data extraction, and risk of bias assessment. We searched electronic databases such as PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP up to September 2016. RCT of treating enamel demineralization with CPP-ACP were included. Data extraction and domain-based risk of bias assessment were independently performed by two reviewers.
Twelve RCTs were included. Because of the difference of experimental design and evaluation standards, the quantitative analysis can not be carried out.
There is no strong evidence that CPP-ACP is superior to conventional fluoride formulations in enamel remineralization. However, due to the limitations of sample size, follow-up time and study design, more high quality and large-sample RCT are needed to further verify the evidence.
本研究旨在通过对使用酪蛋白磷酸肽（CPP）-无定形磷酸钙（ACP）治疗牙釉质脱矿的随机对照试验（RCT）进行系统评价，评估CPP-ACP对牙釉质脱矿的再矿化效果。
本研究基于Cochrane干预系统评价手册（第5.1.0版）开展，包括以下内容：检索策略、选择标准、数据提取和偏倚风险评估。我们检索了截至2016年9月的电子数据库，如PubMed、Embase、Cochrane图书馆、中国知网、万方和维普。纳入使用CPP-ACP治疗牙釉质脱矿的RCT。由两名评价员独立进行数据提取和基于领域的偏倚风险评估。
纳入12项RCT。由于实验设计和评价标准的差异，无法进行定量分析。
没有有力证据表明CPP-ACP在牙釉质再矿化方面优于传统氟化物制剂。然而，由于样本量、随访时间和研究设计的局限性，需要更多高质量、大样本的RCT来进一步验证证据。
