Lareyre Fabien, Raffort Juliette, Le Duy, Chan Hon Lai, Houerou Thomas Le, Cochennec Frédéric, Touma Joseph, Desgranges Pascal
1 Department of Vascular Surgery, Henri Mondor University Hospital, Créteil, Paris, France.
2 Department of Vascular Surgery, University Hospital of Nice, Nice, France.
Angiology. 2018 Sep;69(8):686-691. doi: 10.1177/0003319717751758. Epub 2018 Jan 15.
The predictive value of the neutrophil to lymphocyte ratio (NLR) has been demonstrated in several cardiovascular diseases. The aim of our study was to investigate the association between the preoperative NLR and aneurysm characteristics as well as 30-day postoperative morbidity and mortality in patients with thoracic aortic aneurysm (TAA) undergoing aortic surgical repair. Consecutive patients (n = 75) with TAA were retrospectively included over a 10-year period. Clinical characteristics, aneurysm characteristics, and 30-day postoperative outcome were recorded. The median age of patients was 71 (67-80) years. The median preoperative NLR was 3.5 (2.3-5.8). The proportion of asymptomatic TAA was significantly lower in patients with an NLR > 3.5 compared with those with an NLR < 3.5 (52.6% vs 75.7%; P = .054). The proportion of patients with pain or with ruptured TAA was significantly higher in patients with an NLR > 3.5 compared with those with NLR < 3.5 (42.1% vs 16.2%; P = .022 and 26.3% vs 2.7%; P = .007, respectively). No significant difference was observed regarding the 30-day overall postoperative mortality and morbidity. The preoperative NLR did not correlate with TAA diameter. A high preoperative NLR is significantly associated with symptomatic and ruptured TAA, suggesting a potential interest as a marker and/or player in the disease.
中性粒细胞与淋巴细胞比值（NLR）的预测价值已在多种心血管疾病中得到证实。我们研究的目的是调查接受主动脉手术修复的胸主动脉瘤（TAA）患者术前NLR与动脉瘤特征以及术后30天发病率和死亡率之间的关联。在10年期间回顾性纳入了连续的75例TAA患者。记录了临床特征、动脉瘤特征和术后30天的结果。患者的中位年龄为71（67 - 80）岁。术前NLR的中位数为3.5（2.3 - 5.8）。与NLR < 3.5的患者相比，NLR > 3.5的患者中无症状TAA的比例显著更低（52.6%对75.7%；P = .054）。与NLR < 3.5的患者相比，NLR > 3.5的患者中伴有疼痛或TAA破裂的患者比例显著更高（分别为42.1%对16.2%；P = .022以及26.3%对2.7%；P = .007）。术后30天的总体死亡率和发病率未观察到显著差异。术前NLR与TAA直径无相关性。术前高NLR与有症状和破裂的TAA显著相关，提示其作为该疾病的标志物和/或参与因素可能具有潜在意义。
