Cheong Vee San, Blunn Gordon W, Coathup Melanie J, Fromme Paul
a John Scales Centre for Biomedical Engineering , Institute of Orthopaedics and Musculoskeletal Science, University College London, Royal National Orthopaedics Hospital , Stanmore , UK.
b Department of Mechanical Engineering , University College London , London , UK.
Comput Methods Biomech Biomed Engin. 2018 Feb;21(2):129-138. doi: 10.1080/10255842.2018.1425997. Epub 2018 Jan 16.
Extracortical bone growth with osseointegration of bone onto the shaft of massive bone tumour implants is an important clinical outcome for long-term implant survival. A new computational algorithm combining geometrical shape changes and bone adaptation in 3D Finite Element simulations has been developed, using a soft tissue envelope mesh, a novel concept of osteoconnectivity, and bone remodelling theory. The effects of varying the initial tissue density, spatial influence function and time step were investigated. The methodology demonstrated good correspondence to radiological results for a segmental prosthesis.
皮质外骨生长以及骨与大型骨肿瘤植入物骨干的骨整合是植入物长期存活的重要临床结果。一种新的计算算法已经开发出来，该算法在三维有限元模拟中结合了几何形状变化和骨适应性，使用了软组织包膜网格、骨连接性的新概念以及骨重塑理论。研究了改变初始组织密度、空间影响函数和时间步长的影响。该方法与节段性假体的放射学结果显示出良好的一致性。
