Cerebrovascular Disease Knowledge Portal: An Open-Access Data Resource to Accelerate Genomic Discoveries in Stroke.
作者信息
Crawford Katherine M, Gallego-Fabrega Cristina, Kourkoulis Christina, Miyares Laura, Marini Sandro, Flannick Jason, Burtt Noel P, von Grotthuss Marcin, Alexander Benjamin, Costanzo Maria C, Vaishnav Neil H, Malik Rainer, Hall Jennifer L, Chong Michael, Rosand Jonathan, Falcone Guido J
机构信息
From the Center for Genomic Medicine (K.C., C.G.-F., C.K., S.M., N.V., J.R.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (J.R.), and J. Philip Kistler Stroke Research Center (J.R.), Massachusetts General Hospital, Boston; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA (K.C., C.G.-F., C.K., S.M., J.F., N.B., M.v.G., B.A., M.C., N.V., J.R., G.J.F.); Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, New Haven, CT (L.M., G.J.F.); Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilian University, Munich, Germany (R.M.); Institute for Precision Cardiovascular Medicine, American Heart Association National Center, Dallas, TX (J.L.H.); Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis (J.L.H.); and McMaster University, Hamilton, Ontario, Canada (M.C.).
出版信息
Stroke. 2018 Feb;49(2):470-475. doi: 10.1161/STROKEAHA.117.018922. Epub 2018 Jan 15.
Abstract
摘要
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本文引用的文献
1
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Circulation. 2017 Mar 7;135(10):e146-e603. doi: 10.1161/CIR.0000000000000485. Epub 2017 Jan 25.
2
Dissecting the genetics of complex traits using summary association statistics.利用汇总关联统计剖析复杂性状的遗传学。
Nat Rev Genet. 2017 Feb;18(2):117-127. doi: 10.1038/nrg.2016.142. Epub 2016 Nov 14.
3
Stroke.中风。
Lancet. 2017 Feb 11;389(10069):641-654. doi: 10.1016/S0140-6736(16)30962-X. Epub 2016 Sep 13.
4
Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.中风和小血管疾病额外风险位点的鉴定：全基因组关联研究的荟萃分析
Lancet Neurol. 2016 Jun;15(7):695-707. doi: 10.1016/S1474-4422(16)00102-2. Epub 2016 Apr 7.
5
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration.缺血性卒中的低频和常见基因变异：METASTROKE合作研究
Neurology. 2016 Mar 29;86(13):1217-26. doi: 10.1212/WNL.0000000000002528. Epub 2016 Mar 2.
6
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Lancet Neurol. 2016 Feb;15(2):174-184. doi: 10.1016/S1474-4422(15)00338-5. Epub 2015 Dec 19.
7
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