Enax Joachim, Epple Matthias
Oral Health Prev Dent. 2018;16(1):7-19. doi: 10.3290/j.ohpd.a39690.
Human tooth enamel consists mostly of minerals, primarily hydroxyapatite, Ca10(PO4)6(OH)2, and thus synthetic hydroxyapatite can be used as a biomimetic oral care agent. This review describes the synthesis and characterization of hydroxyapatite from a chemist's perspective and provides an overview of its current use in oral care, with a focus on dentin hypersensitivity, caries, biofilm management, erosion, and enamel lesions.
Reviews and original research papers published in English and German were included.
The efficiency of synthetic hydroxyapatite in occluding open dentin tubules, resulting in a protection for sensitive teeth, has been well documented in a number of clinical studies. The first corresponding studies on caries, biofilm management and erosion have provided evidence for a positive effect of hydroxyapatite either as a main or synergistic agent in oral care products. However, more in situ and in vivo studies are needed due to the complexity of the oral milieu and to further clarify existing results.
Due to its biocompatibility and similarity to biologically formed hydroxyapatite in natural tooth enamel, synthetic hydroxyapatite is a promising biomimetic oral care ingredient that may extend the scope of preventive dentistry.
人类牙釉质主要由矿物质组成，主要是羟基磷灰石，Ca10(PO4)6(OH)2，因此合成羟基磷灰石可用作仿生口腔护理剂。本综述从化学家的角度描述了羟基磷灰石的合成与表征，并概述了其在口腔护理中的当前应用，重点关注牙本质过敏、龋齿、生物膜管理、侵蚀和牙釉质病变。
纳入了以英文和德文发表的综述及原创研究论文。
在多项临床研究中，已充分证明合成羟基磷灰石在封闭开放的牙本质小管方面的有效性，从而为敏感牙齿提供保护。关于龋齿、生物膜管理和侵蚀的首批相应研究已为羟基磷灰石作为口腔护理产品中的主要或协同剂的积极作用提供了证据。然而，由于口腔环境的复杂性，需要更多的原位和体内研究来进一步阐明现有结果。
由于其生物相容性以及与天然牙釉质中生物形成的羟基磷灰石的相似性，合成羟基磷灰石是一种有前景的仿生口腔护理成分，可能会扩展预防牙科的范围。
