心脏保护的 SAFE 途径：这是一个有前途的靶点吗？

The SAFE pathway for cardioprotection: is this a promising target?

机构信息

Hatter Institute for Cardiovascular Research in Africa, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory, Cape Town, 7925, South Africa.

Lionel Opie Preclinical Imaging Core Facility, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.

出版信息

Basic Res Cardiol. 2018 Jan 15;113(2):9. doi: 10.1007/s00395-018-0670-5.

DOI:10.1007/s00395-018-0670-5

PMID:29335904

Abstract

The survivor activating factor enhancement (SAFE) pathway was discovered as an alternative intrinsic pro-survival signaling pathway to the reperfusion injury salvage kinase pathway for cardioprotection against ischemia-reperfusion injury. The delineation of this pathway, made of key components such as cytokines of the immune system and transcription factors, has brought major advancements in our understanding on how the heart is able to protect itself against ischemia-reperfusion injury. In this viewpoint, we describe the major steps leading to the discovery of the SAFE pathway in small animal models to date and we discuss its translation to large animals and humans.

摘要

幸存者激活因子增强 (SAFE) 途径是作为再灌注损伤挽救激酶途径的替代内在生存信号途径而被发现的，用于对抗缺血再灌注损伤的心肌保护。该途径的描绘由免疫系统细胞因子和转录因子等关键组成部分组成，使我们对心脏如何能够防止缺血再灌注损伤有了更深入的理解。在本观点中，我们描述了迄今为止在小动物模型中发现 SAFE 途径的主要步骤，并讨论了其在大型动物和人类中的转化。