远程缺血预处理的免疫和炎症机制：一篇叙述性综述。
Immune and inflammatory mechanism of remote ischemic conditioning: A narrative review.
作者信息
Xu Yi, Wang Yuan, Ji Xunming
机构信息
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
China-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
出版信息
Brain Circ. 2023 Jun 30;9(2):77-87. doi: 10.4103/bc.bc_57_22. eCollection 2023 Apr-Jun.
Abstract
The benefits of remote ischemic conditioning (RIC) on multiple organs have been extensively investigated. According to existing research, suppressing the immune inflammatory response is an essential mechanism of RIC. Based on the extensive effects of RIC on cardiovascular and cerebrovascular diseases, this article reviews the immune and inflammatory mechanisms of RIC and summarizes the effects of RIC on immunity and inflammation from three perspectives: (1) the mechanisms of the impact of RIC on inflammation and immunity; (2) evidence of the effects of RIC on immune and inflammatory processes in ischaemic stroke; and (3) possible future applications of this effect, especially in systemic infectious diseases such as sepsis and sepsis-associated encephalopathy. This review explores the possibility of using RIC as a treatment in more inflammation-related diseases, which will provide new ideas for the treatment of this kind of disease.
摘要
远程缺血预处理（RIC）对多个器官的益处已得到广泛研究。根据现有研究，抑制免疫炎症反应是RIC的重要机制。基于RIC对心血管和脑血管疾病的广泛影响，本文综述了RIC的免疫和炎症机制，并从三个角度总结了RIC对免疫和炎症的影响：（1）RIC对炎症和免疫影响的机制；（2）RIC对缺血性卒中免疫和炎症过程影响的证据；（3）这种效应未来可能的应用，特别是在脓毒症和脓毒症相关脑病等全身性感染性疾病中的应用。本综述探讨了将RIC用作更多炎症相关疾病治疗方法的可能性，这将为这类疾病的治疗提供新思路。
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