Das Sanjoy Kumar, Chakraborty Soumalya, Roy Chhandita, Rajabalaya Rajan, Mohaimin Amal Widaad, Khanam Jasmina, Nanda Arunabha, David Sheba R
Institute of Pharmacy, Jalpaiguri, Pin 735101, West Bengal, India.
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Curr Drug Deliv. 2018;15(6):795-817. doi: 10.2174/1567201815666180116091604.
In the study of lipid vesicular carriers in permeation enhancement of drug molecules across skin after the success story of liposomes, ethosomes are a recent addition. There are a number of published reviews but still, there is a lack of reviews representing various aspects in a systematic way with a detailed description of current research works. This review serves to fill this deficiency along with special emphasize on its preparation methods and applications.
Information was collected from previously published literatures which were represented after analysis in terms of various aspects such as principles, composition, preparation, mechanism of penetration, modified forms, characterization, marketed preparations and its applications.
This review is represented in an informative and easily understandable way. Basic principles and background were covered in the introduction section. Composition section contains the basic components of formulations along with the impact of various parameters on the characterization of the ethosome. A detailed discussion of all the methods along with their own utility is elaborately provided. Various aspects of characterization studies of ethosomes are also discussed. Therapeutic and cosmetic applications of ethosomes are also outlined here.
In spite of having a excellent permeation-enhancing and targeted drug release profile, ethosome suffers from limited commercialization. Various challenges regarding their commercialization and product development are also discussed in this review with an objective of acting as a directional route for the researchers.
在脂质体成功实现药物分子经皮渗透增强的研究之后，乙醇脂质体是脂质囊泡载体研究中的新成员。虽然已经有许多发表的综述，但仍然缺乏以系统方式涵盖各个方面并详细描述当前研究工作的综述。本综述旨在填补这一空白，并特别强调其制备方法和应用。
从先前发表的文献中收集信息，这些文献在分析后按原理、组成、制备、渗透机制、修饰形式、表征、上市制剂及其应用等各个方面进行了阐述。
本综述以信息丰富且易于理解的方式呈现。引言部分涵盖了基本原理和背景。组成部分包含制剂的基本成分以及各种参数对乙醇脂质体表征的影响。详细讨论了所有方法及其各自的用途。还讨论了乙醇脂质体表征研究的各个方面。此处还概述了乙醇脂质体的治疗和美容应用。
尽管乙醇脂质体具有出色的渗透增强和靶向药物释放特性，但商业化程度有限。本综述还讨论了其商业化和产品开发方面的各种挑战，旨在为研究人员提供一条指导路径。
