Prasitsuebsai Wasana, Sethaputra Chuenkamol, Lumbiganon Pagakrong, Hansudewechakul Rawiwan, Chokephaibulkit Kulkanya, Truong Khanh Huu, Nguyen Lam Van, Mohd Razali Kamarul Azahar, Nik Yusoff Nik Khairulddin, Fong Moy Siew, Teeraananchai Sirinya, Ananworanich Jintanat, Durier Nicolas
a The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT) , The Thai Red Cross AIDS Research Centre , Bangkok , Thailand.
b TREAT Asia/amfAR-The Foundation for AIDS Research , Bangkok , Thailand.
AIDS Care. 2018 Jun;30(6):727-733. doi: 10.1080/09540121.2018.1425363. Epub 2018 Jan 16.
We studied behavioral risks among HIV-infected and uninfected adolescents using an audio computer-assisted self-interview. A prospective cohort study was initiated between 2013 and 2014 in Malaysia, Thailand, and Vietnam. HIV-infected adolescents were matched to uninfected adolescents (4:1) by sex and age group (12-14 and 15-18 years). We enrolled 250 HIV-infected (48% male; median age 14.5 years; 93% perinatally infected) and 59 uninfected (51% male; median age 14.1 years) adolescents. At enrollment, HIV-infected adolescents were on antiretroviral therapy (ART) for a median (IQR) of 7.5 (4.7-10.2) years, and 14% had HIV-RNA >1000 copies/mL; 19% reported adherence <80%. Eighty-four (34%) HIV-infected and 26 (44%) uninfected adolescents reported having ever smoked cigarettes or drunk alcohol (p = 0.13); 10% of HIV-infected and 17% of uninfected adolescents reported having initiated sexual activity; 6 of the HIV-infected adolescents had HIV-RNA >1000 copies/mL. Risk behaviors were common among adolescents, with few differences between those with and without HIV.
我们使用音频计算机辅助自我访谈研究了感染艾滋病毒和未感染艾滋病毒的青少年的行为风险。2013年至2014年期间在马来西亚、泰国和越南开展了一项前瞻性队列研究。按性别和年龄组（12 - 14岁和15 - 18岁）将感染艾滋病毒的青少年与未感染艾滋病毒的青少年以4:1的比例进行匹配。我们招募了250名感染艾滋病毒的青少年（48%为男性；中位年龄14.5岁；93%为围产期感染）和59名未感染艾滋病毒的青少年（51%为男性；中位年龄14.1岁）。在入组时，感染艾滋病毒的青少年接受抗逆转录病毒治疗（ART）的中位时间（四分位间距）为7.5（4.7 - 10.2）年，14%的人艾滋病毒核糖核酸（HIV - RNA）>1000拷贝/毫升；19%的人报告依从性<80%。84名（34%）感染艾滋病毒的青少年和26名（44%）未感染艾滋病毒的青少年报告曾经吸烟或饮酒（p = 0.13）；10%的感染艾滋病毒的青少年和17%的未感染艾滋病毒的青少年报告开始有性行为；6名感染艾滋病毒的青少年的HIV - RNA>1000拷贝/毫升。风险行为在青少年中很常见，感染艾滋病毒和未感染艾滋病毒的青少年之间差异不大。
