Mejía Wilson, Córdoba Diana, Durán Paola, Chacón Yersson, Rosselli Diego
a Pontificia Universidad Javeriana , Nutrition Biochemistry Department , Bogota , Colombia.
b Centro de Endocrinología Pediátrica y del Adolescente , Bogota , Colombia.
J Diet Suppl. 2019;16(1):1-13. doi: 10.1080/19390211.2017.1409851. Epub 2018 Jan 16.
A soy protein-based supplement may optimize bone health, support physical growth, and stimulate bone formation. This study aimed to assess the effect of a daily soy protein supplement (SPS) on nutritional status, bone formation markers, lipid profile, and daily energy and macronutrient intake in children. One hundred seven participants (62 girls), ages 2 to 9, started the study and were randomly assigned to lunch fruit juice with (n = 57, intervention group) or without (n = 50, control group) addition of 45 g (230 Kcal) of a commercial SPS during 12 months; 84 children (51 girls, 33 boys) completed the study (45 and 39 intervention and control, respectively). Nutritional assessment included anthropometry and nutrient intakes; initial and final blood samples were taken; insulin-like growth factor-I (IGF-I), osteocalcin, bone specific alkaline phosphatase (BAP), insulin-like growth factor binding protein-3 (IGFBP-3), cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were analyzed. Statistically significant changes (p < .05) in body mass index and weight for age Z scores were observed between groups while changes in body composition were not. Changes in energy, total protein, and carbohydrate intakes were significantly higher in the intervention group (p < .01). Calorie intake changes were statistically significant between groups (p < .001), and BAP decreased in both groups, with values within normal ranges. Osteocalcin, IGFBP-3, and lipid profile were not different between groups. IGF-I levels and IGF/IGFBP-3 ratio increased significantly in both groups. In conclusion, changes in macronutrient and energy intake and nutritional status in the intervention group compared to control group may ensure harmonious and adequate bone health and development.
一种基于大豆蛋白的补充剂可能会优化骨骼健康、支持身体生长并刺激骨骼形成。本研究旨在评估每日补充大豆蛋白（SPS）对儿童营养状况、骨形成标志物、血脂谱以及每日能量和常量营养素摄入量的影响。107名年龄在2至9岁的参与者（62名女孩）开始了这项研究，并被随机分配在12个月内饮用添加（n = 57，干预组）或不添加（n = 50，对照组）45克（230千卡）市售SPS的午餐果汁；84名儿童（51名女孩，33名男孩）完成了研究（干预组和对照组分别为45名和39名）。营养评估包括人体测量学和营养素摄入量；采集了初始和最终血样；分析了胰岛素样生长因子-I（IGF-I）、骨钙素、骨特异性碱性磷酸酶（BAP）、胰岛素样生长因子结合蛋白-3（IGFBP-3）、胆固醇、甘油三酯、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）。两组之间观察到体重指数和年龄别体重Z评分有统计学显著变化（p < 0.05），而身体成分变化无显著差异。干预组的能量、总蛋白和碳水化合物摄入量变化显著更高（p < 0.01）。两组之间的卡路里摄入量变化有统计学显著差异（p < 0.001），两组的BAP均下降，且值在正常范围内。两组之间的骨钙素、IGFBP-3和血脂谱无差异。两组的IGF-I水平和IGF/IGFBP-3比值均显著升高。总之,与对照组相比，干预组常量营养素和能量摄入量以及营养状况的变化可能确保骨骼健康和发育的和谐与充足。
